Table 2.
Complications found in each study of the qualitative systematic review. The percentages refer to patients with complications.
| Article | Complications Related to Adipose Tissue Harvesting Procedure |
Local or Systemic Complications Related to MM-AT Injection |
|---|---|---|
| Aletto et al., 2022 [27] | / | / |
| Barfod et al., 2019 [28] | Cosmetic changes to the abdominal subcutaneous tissue (5%) | / |
| Baria et al., 2022 [29] | / | / |
| Boric et al., 2019 [30] | n.r. | n.r. |
| Cattaneo et al., 2018 [31] | Temporary and small subcutaneous hematoma (2.9%) |
/ |
| Dallo et al., 2021 [32] | / | / |
| Fan et al., 2023 [33] | n.r. | n.r. |
| Ferracini et al., 2022 [34] | / | Painful adipose loose bodies (2.2%), recurrent episodes of joint effusion (2.2%) |
| Giorgini et al., 2022 [35] | Hematoma (2.2%) | Knee swelling (8.9%) |
| Gobbi et al., 2021 [36] | Donor site pain (49%), swelling/bruising (28%) |
Knee prolonged swelling (13%) |
| Gobbi et al., 2023 [37] | ||
| Heidari et al., 2021 [38] | Donor site bleeding (4.1%), pain (6.4%) | Joint swelling and pain (21.8%), severe reaction requiring wash-out of the joint (0.45%) |
| Heidari et al., 2020 [39] | / | / |
| Hudetz et al., 2019 [40] | / | / |
| Hudetz et al., 2017 [41] | / | / |
| Kaszynski et al., 2022 [42] | n.r. | n.r. |
| Malanga et al., 2021 [43] | Donor site erythema and swelling (1%), soreness (52.5%), and hematoma (15%) |
Knee swelling (15%) |
| Magnanelli et al., 2020 [44] | n.r. | n.r. |
| Mautner et al., 2019 [45] | n.r. | n.r. |
| Miles et al., 2022 [46] | / | / |
| Panchal et al., 2018 [47] | / | Knee pain and swelling |
| Peretti et al., 2018 [48] | n.r. | n.r. |
| Pintore et al., 2023 [49] | / | / |
| Priano et al., 2022 [50] | / | Knee crepitus on motion (32%) and effusion (4%) |
| Russo et al., 2017 [51] | Donor site hematoma (6.7%) | Recurrent knee effusions (3.3%) |
| Russo et al., 2018 [52] | / | / |
| Santoprete et al., 2021 [53] | Donor site discomfort and pain (15%) | Knee swelling and pain (7%) |
| Screpis et al., 2022 [54] | / | / |
| Ulivi et al., 2022 [55] | Donor site small hematoma | / |
| Van Genechten et al., 2021 [56] | / | Subjective knee instability (3.6%), muscle aching in the calves (1.8%), gallstones (1.8%), stroke (3.6%), tendinopathy (5.4%) |
| Vasso et al., 2022 [57] | Donor site transitory hematoma (8.7%) | / |
| Yu et al., 2023 [58] | / | / |
| Zaffagnini et al., 2022 [59] | / | MM-AT: mild/moderate knee pain, joint swelling, and/or effusion (18.5%); PRP: knee pain, joint swelling, and/or effusion (11.1%) |