Table 6.
List of other lipids that may be involved in various types of cancer.
Lipids | Composition | Presence of the Side of Membrane | Cancer Types | Levels | Functions | Ref. |
---|---|---|---|---|---|---|
Phosphoinositide | Phosphate group, two fatty acid chain and inositol molecule | Primarily located inner leaflet | Breast, Prostate, Ovarian, Lung, and Gastric | Increased | Signaling for cell proliferation and motility | [363,364,365,366] |
Cholesterol | Sterol composed of four hydrocarbon rings, and a hydroxyl group | Primarily located outer leaflet | Most types | Alteration | Controlling membrane structure | [368] |
Prostaglandin | Five member ring with fatty acid, arachidonic acid | Primarily located inner leaflet | Most types | Secreted by cancer cells | Angiogenesis, anti-apoptosis, invasion | [369] |
lysophosphatidic acid | Contains a glycerol backbone with a phosphoryl group | Primarily located outer leaflet | Ovarian | Increased | Enhanced metastasis | [370,371,372] |
sphingosine 1 phosphate | Amphipatic lysophospholipid composed of a sphingoid extended chain and a phosphate molecule. | Primarily located outer leaflet | Most types | Secreted by cancer cells | Angiogenesis | [373,374,375,376] |
Ceramides | Contains sphingosine and a fatty acid | Both leaflets | Breast, Prostate, and Ovarian | Decreased level | Cell cycle arrest and apoptosis | [368] |