Phosphoinositide |
Phosphate group, two fatty acid chain and inositol molecule |
Primarily located inner leaflet |
Breast, Prostate, Ovarian, Lung, and Gastric |
Increased |
Signaling for cell proliferation and motility |
[363,364,365,366] |
Cholesterol |
Sterol composed of four hydrocarbon rings, and a hydroxyl group |
Primarily located outer leaflet |
Most types |
Alteration |
Controlling membrane structure |
[368] |
Prostaglandin |
Five member ring with fatty acid, arachidonic acid |
Primarily located inner leaflet |
Most types |
Secreted by cancer cells |
Angiogenesis, anti-apoptosis, invasion |
[369] |
lysophosphatidic acid |
Contains a glycerol backbone with a phosphoryl group |
Primarily located outer leaflet |
Ovarian |
Increased |
Enhanced metastasis |
[370,371,372] |
sphingosine 1 phosphate |
Amphipatic lysophospholipid composed of a sphingoid extended chain and a phosphate molecule. |
Primarily located outer leaflet |
Most types |
Secreted by cancer cells |
Angiogenesis |
[373,374,375,376] |
Ceramides |
Contains sphingosine and a fatty acid |
Both leaflets |
Breast, Prostate, and Ovarian |
Decreased level |
Cell cycle arrest and apoptosis |
[368] |