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. 2023 Dec 20;24(1):37. doi: 10.3390/s24010037

Table 6.

List of other lipids that may be involved in various types of cancer.

Lipids Composition Presence of the Side of Membrane Cancer Types Levels Functions Ref.
Phosphoinositide Phosphate group, two fatty acid chain and inositol molecule Primarily located inner leaflet Breast, Prostate, Ovarian, Lung, and Gastric Increased Signaling for cell proliferation and motility [363,364,365,366]
Cholesterol Sterol composed of four hydrocarbon rings, and a hydroxyl group Primarily located outer leaflet Most types Alteration Controlling membrane structure [368]
Prostaglandin Five member ring with fatty acid, arachidonic acid Primarily located inner leaflet Most types Secreted by cancer cells Angiogenesis, anti-apoptosis, invasion [369]
lysophosphatidic acid Contains a glycerol backbone with a phosphoryl group Primarily located outer leaflet Ovarian Increased Enhanced metastasis [370,371,372]
sphingosine 1 phosphate Amphipatic lysophospholipid composed of a sphingoid extended chain and a phosphate molecule. Primarily located outer leaflet Most types Secreted by cancer cells Angiogenesis [373,374,375,376]
Ceramides Contains sphingosine and a fatty acid Both leaflets Breast, Prostate, and Ovarian Decreased level Cell cycle arrest and apoptosis [368]