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. 2023 Dec 24;16(1):58. doi: 10.3390/nu16010058

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of OLE-JGF on hepatic lipogenesis, mitochondrial biogenesis, and thermogenesis in HFD-fed mice. (A–C) Relative mRNA expression of hepatic-lipogenesis-related genes (A) SREBP-1c, (B) ACC, and (C) FAS in liver tissue. (D–F) Relative mRNA expression of mitochondrial-biogenesis-related genes: (D) PGC-1α, (E) Nrf2, and (F) Tfam. (G,H) Relative mRNA expression of markers for (G) the number of mitochondria (mtDNA) and (H) the thermogenesis-related gene (UCP2) in liver tissue. Data are presented as mean ± SEM (n = 6–8). Differences were assessed using one-way ANOVA test followed by multiple group comparisons. * p < 0.05 and ** p < 0.01; ns, not significance.