Table 4.
Diagnostic performance metrics of 2D shear wave elastography and liver fibrosis scores in NAFLD-positive participants.
| Screening Tool | Sensitivity | Specificity | PPV | NPV | PLR | NLR | Accuracy |
|---|---|---|---|---|---|---|---|
| 2D-SWE | 71.4% | 75% | 83.3% | 60% | 2.9 | 0.4 | 72.7% |
| FIB-4 index | 100% | 50% | 77.8% | 100% | 2.0 | 0 | 81.8% |
| APRI | 42.9% | 100% | 100% | 50% | - | 0.6 | 63.6% |
| FAP index | 75.0% | 33.3% | 75.0% | 33.3% | 1.1 | 0.8 | 63.6% |
| Combination of 2D-SWE and FIB-4 index | 88.8% | 50% | 88.8% | 50% | 1.8 | 0.2 | 81.8% |
| Combination of 2D-SWE and APRI | 62.5% | 66.6% | 83.3% | 40% | 1.8 | 0.6 | 63.6% |
| Combination of 2D-SWE and FAP index | 87.5% | 33.3% | 77.8% | 50% | 1.3 | 0.4 | 72.7% |
| Combination of 2D-SWE, FIB-4 index, APRI, and FAP index | 100% | 33.3% | 80% | 100% | 1.5 | 0 | 81.8% |
2D-SWE: 2D shear wave elastography; APRI: AST (aspartate aminotransferase)-to-platelet ratio index; FAP: fibroblast activation protein; FIB-4: Fibrosis-4; NLR: negative likelihood ratio; NPV: negative predictive value; PLR: positive likelihood ratio; PPV: positive predictive value.