TABLE 4.

Multivariate analysis of risk factors of 28-day/90-day mortality in those patients with ACLF of diagnosis based on Fine-Gray test

	28-day				90-day
	Model 1		Model 2		Model 1		Model 2
	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p
Age	1.04 (1.03–1.06)	<0.001	1.04 (1.03–1.06)	<0.001	1.04 (1.02–1.05)	<0.001	1.04 (1.02–1.05)	<0.001
Infection at enrollment	—	—	—	—	—	—	1.46 (1.02–2.07)	0.037
HE at enrollment	1.78 (1.20–2.65)	<0.001	2.02 (1.34–3.05)	<0.001	1.59 (1.14–2.20)	0.006	1.76 (1.26–2.46)	0.001
PLT(*10E9/L)	—	—	—	—	—	—	1.00 (0.99–1.00)	0.035
Serum sodium (mmol/L)	0.95 (0.92–0.98)	<0.001	0.95 (0.92–0.98)	<0.001	0.95 (0.92–0.97)	<0.001	0.95 (0.93–0.97)	<0.001
ALT (U/L)	1.00 (1.00–1.00)	<0.001	1.00 (1.00–1.00)	<0.001	1.00 (1.00–1.00)	<0.001	1.00 (1.00–1.00)	<0.001
Total bilirubin(mol/L)	1.00 (1.00–1.00)	<0.001	1.00 (1.00–1.00)	<0.001	1.00 (1.00–1.00)	0.002	1.00 (1.00–1.00)	0.001
INR	—	—	—	—	1.11 (1.00–1.23)	0.049	1.12 (1.01–1.24)	0.027
New onset of HE	—	—	2.68 (1.64–4.38)	<0.001	—	—	2.55 (1.63–3.98)	<0.001
New onset of infection	—	—	—	—	—	—	1.76 (1.02–3.04)	0.043

Notes: Model 1: age, sex, presence of HE at enrollment, GIH at enrollment, ascites at enrollment, infection at enrollment, ALT at enrollment, Serum sodium at enrollment, PLT at enrollment, NLR at enrollment, bilirubin at enrollment, Cr at enrollment, and INR at enrollment.

Model 2: age, sex, presence of HE at enrollment, GIH at enrollment, ascites at enrollment, infection at enrollment, ALT at enrollment, Serum sodium at enrollment, PLT at enrollment, NLR at enrollment, bilirubin at enrollment, Cr at enrollment, INR at enrollment, new onset of ascites, new onset of HE, and new onset of infection.

Abbreviations: ALT, alanine aminotransferase; Cr, creatinine; GIH, gastrointestinal haemorrhage; INR, international normalized ratio; NLR, neutrophil-to-lymphocyte ratio; PLT, platelet count; PLT, platelet count.