Table 4.
Unadjusted and Adjusted Cause-Specific Proportional Hazard Model for Fidaxomicin vs Vancomycin
| Hazard Ratio (95% CI) | ||
|---|---|---|
| Unadjusted Model | Adjusted Modela | |
| Composite outcomeb: fidaxomicin | 0.54 (.19–1.51) | 0.28 (.08–.93) |
| Secondary outcomes | ||
| Clinical failure | 2.56 (.47–14.0) | 0.89 (.09–8.67) |
| Relapse | ||
| 30 d | 0.21 (.03–1.56) | 0.15 (.02–1.15) |
| 90 d | 0.65 (.15–2.87) | 0.50 (.11–2.35) |
| Total | 0.36 (.11–1.18) | 0.27 (.08–.91) |
| CDI-related death | 0.56 (.07–4.45) | 0.31 (.04–2.67) |
Other causes of death: adjusted hazard ratio for composite outcome, 3.3 (95% CI, 0.90–11.70).
Abbreviation: CDI, Clostridioides difficile infection.
aAdjusted for sex, number of antecedent antibiotics, CDI severity, and type of immunosuppression.
bComposite outcome: clinical failure, relapse at 30 days, and death related to CDI.