Figure 11.

ROC curve analysis of the six key exo-miRNAs. (A) hsa-miR-222-3p. (B) hsa-miR-221-3p. (C) hsa-miR-199ª-5p. (D) hsa-miR-223-3p. (E) hsa-miR-151ª-3p. (F) hsa-miR-877-5p. The ROC curves to discriminate the BM- group from healthy controls (H) in the validation set are marked by red lines; the ROC curves to differentiate the BM+ group from the BM- group in the validation set are marked by blue lines; the ROC curves to differentiate the BM+ group from H in the validation set are marked by green lines. Abbreviations: ROC: receiver operator characteristic curve; BM+: patients with bone metastasis; BM−: patients without bone metastasis.