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. 2023 Dec 20;625(7994):385–392. doi: 10.1038/s41586-023-06857-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — a-c, Graphs depicting Kaplan-Meier survival curve (a), body weight (b) serum levels of glucose, total cholesterol, TAGs, HDL- and LDL-cholesterol (c) of Sdha^fl/fl (n = 29 (a), n = 30 (b), n = 19 (glucose, HDL- and LDL- cholesterol), n = 24 (total cholesterol, TAG) (c)) and SDHA^IEC-KO (n = 32 (a), n = 31 (b), n = 17 (glucose, HDL- and LDL-cholesterol), n = 22 (total cholesterol, TAG) (c)) mice at the age of 7 days. d, Representative images of SI sections from Sdha^fl/fl and SDHA^IEC-KO mice stained with H&E, COX-SDH and ORO or immunostained for PLIN2 and Ki67. Scale bars, 50 μm. e, Immunoblot analysis of IEC protein extracts from 7-day-old Sdha^fl/fl (n = 4) and SDHA^IEC-KO (n = 3) mice with the indicated antibodies. f, g, h Graphs depicting Kaplan-Meier survival curve (f), body weight (g) serum levels of glucose, total cholesterol, TAGs, HDL- and LDL-cholesterol (h) of 7-day-old Cox10^fl/fl (n = 35 (f), n = 18 (g), n = 11 (glucose, HDL- and LDL-cholesterol), n = 18 (total cholesterol, TAG) (h)) and COX10^IEC-KO (n = 37 (f), n = 21 (g), n = 7 (glucose, HDL- and LDL-cholesterol), n = 22 (total cholesterol, TAG) (h)) mice. i, Representative images of SI sections from Cox10^fl/fl and COX10^IEC-KO mice stained with H&E, COX-SDH and ORO or immunostained for PLIN2 and Ki67. Scale bars, 50 μm. j, Immunoblot analysis of IEC protein extracts from 7-day-old Cox10^fl/fl (n = 5) and COX10^IEC-KO (n = 4) mice with the indicated antibodies. In b, c, g and h, dots represent individual mice, bar graphs show mean ± s.e.m. and P values were calculated by two-sided nonparametric Mann-Whitney U -test. In a and f, P values were calculated by two-sided Gehan-Breslow-Wilcoxon test. In d and i, histological images shown are representative of the number of mice analysed as indicated in Supplementary Table 4. In i and j, each lane represents one mouse and α-tubulin was used as loading control. For gel source data, see Supplementary Fig. 1.

Source Data