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. 2023 Dec 20;625(7994):401–409. doi: 10.1038/s41586-023-06872-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, Correlation of genome-wide RT values between the indicated stages of preimplantation embryos using Spearman’s R. b,c, Characterization of RT in parthenogenetic zygotes. Heatmaps show replication states in parthenogenetic embryos (b) and corresponding average RT profiles (c). d, Smoothed scatterplot of RT values in normal versus parthenogenetic zygotes. Spearman’s correlation (R_s) is indicated. e,f, Characterization of RT in physically isolated maternal and paternal pronuclei (PN). Heatmaps show replication states in each pronucleus (e) and corresponding average RT profiles (f) of the chromosome 2 region, indicated by the black rectangle. g, Smoothed scatterplot of RT values in zygotes compared with isolated maternal and paternal pronuclei. Spearman’s correlation is indicated. h, Smoothed scatterplot of RT values comparing maternal or paternal pronucleus and parthenogenetic zygotes, as indicated. Spearman’s correlation is indicated. i, RT values of RT peaks, TTRs and RT troughs in isolated maternal and paternal pronuclei. Box plots show median and IQR, whiskers depict the lowest and highest values within 1.5× IQR.