Fig. 3. RT heterogeneity decreases with developmental progression, and segregation between early and late RT values increases.
a, Violin plots showing relative RT heterogeneity (Twidth), which is the replication score difference between 25 and 75% of cells replicating the 50 kb bin, in embryonic development and in mouse embryonic stem (ES) cells. Dots indicate median. b, Contour plot showing Twidth along progression of RT in mouse embryos. RT peaks, TTRs and RT troughs are indicated. c, Violin plots showing RT mid-point value (M-value), which is the replication score at which 50% of cells replicated the 50 kb bin during embryonic development and in mouse ES cells. Dots indicate median.