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. 2023 Apr 28;21:2929–2939. doi: 10.1016/j.csbj.2023.04.026

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© 2023 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 4 — The SD motif and 8-mer distribution of BAGAN-GP-generated cRBSs. (A) The sequence logos of trained cRBSs and BAGAN-GP-generated cRBS sequences in five sub-libraries. (B) The 8-mer scatter plot showing trained cRBSs and generated cRBSs with desired TFB dynamic ranges. Each point represents a certain 8-mer. The x- and y-axes represent 8-mer frequencies in trained and generated cRBSs with selected TFB dynamic ranges. (C) R-squared analyses the correlations of 8-mer frequencies in step n (n = 1, 5, 10, 15, 20) between trained cRBSs and BAGAN-GP-generated cRBSs from sub-libraries I–V. SDm and SDn represent SD sequences controlling sfgfp and cdaR translation.