Table 2.

GI bleeding in a meta-analysis of data from 11 RCTs [39] (average duration 2.8 years).

Bleeding	Risk of a bleed (in 2.8 years)	Relative risk for aspirin
Incidence of a GI bleed
- in 54,625 subjects randomised to aspirin	8 per 1000	RR 1.55
- in 52,583 subjects randomised to placebo	5 per 1000	(1.32, 1.83)
Proportion of bleeds that were fatal
- in subjects on aspirin	4%	RR = 0.45
- in subjects on placebo	8%	(0.25, 0.80)
Risk of a fatal bleed in trial participants
- randomised to aspirin	3.7/10,000	RR = 0.77
- randomised to placebo	4.7/10,000	(0.41, 1.43)