Table 2.

Documented or Probable Reasons for Prolonged Isolation >20 Days

Consistency with CDC Isolation Guidelines	Reason	Total (N = 113), No. (%)
Inconsistent (N = 28)	Unclear reasons	13 (12)
	Persistent oxygen requirement (≤4 L/m)	15 (13)
Questionable (N = 61)	Respiratory failure requiring mechanical ventilation, noninvasive mechanical ventilation, or oxygen >4 L/m	34 (30)
	Respiratory failure and shock	27 (24)
Consistent (N = 24)	Moderately or severely immunocompromised	24 (21)
	Hematologic malignancy not on treatment	3
	Hematologic malignancy on treatment a	2
	Active cancer not on treatment	6
	Active cancer on treatment a, b, c	4
	Solid-organ transplant on treatment a, b	5
	Autoimmune disorders, and other medical illnesses on treatment‡	4

^a Immunosuppressive agents used in treatment of malignancies, autoimmune disorders, and other medical illnesses.

^b Steroid use of ≥20 mg prednisone or equivalent per day when administered for ≥2 weeks.

^c Some patient received steroids in addition to other immunosuppressive agent.