Table 1.
Summary of Studies on CIT Identified Risk of Sinus Sequestration With TAV-in-TAV
| First Author, Year | Country of Origin | Definition of Sinus Sequestration | Reported Risk of Sinus Sequestration for Future Redo TAVR in ≥1 Coronary Artery | Proportion With Risk Not Potentially Remediable Using Leaflet Modification Procedures (%) |
|---|---|---|---|---|
| Miyawaki, 2023 (n = 1,122)11 | Japan | TAVR commissure level located above the STJ AND THV-to-STJ distance <2.0 mm in each coronary sinus |
52.1% Sapien S3 (BEV), 71.3% Evolut R/Pro (SEV) | BEV: 6.5% LCA, 5.3% RCA SEV: 45.0% LCA, 46.7% RCA |
| Ochiai, 2023 (n = 418)12 | Japan | TAVR commissure level located above the STJ AND THV-to-STJ distance <2.0 mm in each coronary sinus |
17.6% in the HIT group (n = 108) and 5.3% of patients in the CIT group (n = 150) for Sapien S3 (BEV) 64.0% in the HIT group (n = 50) and 41.8% in the CIT group with Evolut R/PRO/PRO + (SEV) |
BEV: 9.5% HIT, 12.5% CIT SEV: 39.6% HIT, 52.9% CIT |
| Ochiai, 2020 (n = 411)13 | United States | TAVR commissure level above the STJ and distance between TAV OR THV-STJ distance <2.0 mm in each coronary sinus |
2% Sapien S3 (BEV), 45.5% Evolut R/Pro (SEV) | BEV: 11.9% SEV: 45.2% |
| Sato, 2023 (n = 308)14 | Japan | TAVR commissure level located above the STJ AND THV-to-STJ distance <2.0 mm in each coronary sinus |
39% Sapien S3 (BEV) | NA |
| Chen, 2022 (n = 288)15 | China | 1) Both the VTSTJ and STJ-commissure distances were <2.0 mm if the THV commissure level was between the coronary ostium and the STJ OR 2) either the VTSTJ distance or the VTA distance was <2.0 mm if the THV commissure level was above the STJ |
25.7% VenusA-valve (SEV) | 61.5% for LCA, 58.8% for RCA |
| Forrestal, 2022 (n = 81)16 | United States | TAVR commissure level located above the STJ AND THV-to-STJ distance <2.0 mm in each coronary sinus |
23% Evolut PRO/PRO + (SEV) | NA |
| Rogers, 2020 (n = 137)17 | United States | TAVR commissure level located above the STJ AND THV-to-STJ distance <2.0 mm in each coronary sinus |
13.1% Sapien S3 (BEV) | 8.7% |
BEV = balloon-expandable valve; CIT = conventional implantation technique; HIT = high implantation technique; LCA = left coronary artery; NA = not available; RCA = right coronary artery; SEV = self-expanding valve; TAVR = transcatheter aortic valve replacement; THV = transcatheter heart valve; STJ = sinotubular junction; VTA = virtual transcatheter valve to aorta; VTSTJ = virtual transcatheter heart valve to sinotubular junction.