Table 4.
Risk of all-cause, cardiometabolic, cancer and other-cause mortality, for models that include both sleep regularity and sleep duration (model 3)
| Model | Percentile | All-cause | Cardiometabolic | Cancer | Other-cause | ||||
|---|---|---|---|---|---|---|---|---|---|
| N (%) | HR [95% CI] | N (%) | HR [95% CI] | N (%) | HR [95% CI] | N (%) | HR [95% CI] | ||
| Minimal | SRI (0%–20%) | 565 (0.93) | — | 130 (0.21) | — | 294 (0.48) | — | 140 (0.23) | — |
| N = 60 780 | SRI (20%–40%) | 389 (0.64) | 0.73 [0.64 to 0.83]*** | 79 (0.13) | 0.70 [0.52 to 0.92]* | 230 (0.38) | 0.81 [0.68 to 0.97]* | 80 (0.13) | 0.62 [0.47 to 0.82]*** |
| SRI (40%–60%) | 322 (0.53) | 0.64 [0.56 to 0.74]*** | 61 (0.1) | 0.60 [0.44 to 0.82]** | 204 (0.34) | 0.75 [0.62 to 0.89]** | 56 (0.09) | 0.47 [0.34 to 0.64]*** | |
| SRI (60%–80%) | 284 (0.47) | 0.56 [0.49 to 0.65]*** | 49 (0.08) | 0.49 [0.35 to 0.69]*** | 182 (0.3) | 0.66 [0.55 to 0.80]*** | 50 (0.08) | 0.42 [0.30 to 0.58]*** | |
| SRI (80%–100%) | 288 (0.47) | 0.54 [0.47 to 0.63]*** | 55 (0.09) | 0.52 [0.38 to 0.73]*** | 176 (0.29) | 0.60 [0.50 to 0.73]*** | 56 (0.09) | 0.44 [0.32 to 0.60]*** | |
| Duration (0%–20%) | 502 (0.83) | — | 129 (0.21) | — | 257 (0.42) | — | 114 (0.19) | — | |
| Duration (20%–40%) | 340 (0.56) | 0.87 [0.75 to 1.00] | 67 (0.11) | 0.73 [0.54 to 0.99]* | 200 (0.33) | 0.95 [0.79 to 1.14] | 72 (0.12) | 0.89 [0.66 to 1.20] | |
| Duration (40%–60%) | 323 (0.53) | 0.88 [0.77 to 1.02] | 64 (0.11) | 0.76 [0.55 to 1.04] | 198 (0.33) | 0.99 [0.82 to 1.20] | 60 (0.1) | 0.81 [0.59 to 1.11] | |
| Duration (60%–80%) | 314 (0.52) | 0.84 [0.73 to 0.98]* | 52 (0.09) | 0.61 [0.43 to 0.85]** | 204 (0.34) | 1.00 [0.83 to 1.21] | 58 (0.1) | 0.77 [0.55 to 1.06] | |
| Duration (80%–100%) | 369 (0.61) | 0.93 [0.81 to 1.08] | 62 (0.1) | 0.67 [0.49 to 0.92]* | 227 (0.37) | 1.06 [0.88 to 1.27] | 78 (0.13) | 0.95 [0.71 to 1.29] | |
| Full | SRI (0%–20%) | 434 (0.93) | — | 96 (0.21) | — | 231 (0.49) | — | 106 (0.23) | — |
| N = 46 721 | SRI (20%–40%) | 296 (0.63) | 0.83 [0.71 to 0.96]* | 61 (0.13) | 0.85 [0.61 to 1.17] | 170 (0.36) | 0.84 [0.69 to 1.03] | 65 (0.14) | 0.83 [0.61 to 1.13] |
| SRI (40%–60%) | 249 (0.53) | 0.78 [0.66 to 0.92]** | 50 (0.11) | 0.81 [0.57 to 1.16] | 155 (0.33) | 0.83 [0.68 to 1.02] | 44 (0.09) | 0.67 [0.46 to 0.96]* | |
| SRI (60%–80%) | 226 (0.48) | 0.75 [0.64 to 0.89]** | 45 (0.1) | 0.80 [0.55 to 1.18] | 139 (0.3) | 0.77 [0.62 to 0.96]* | 39 (0.08) | 0.65 [0.44 to 0.95]* | |
| SRI (80%–100%) | 221 (0.47) | 0.74 [0.62 to 0.89]*** | 41 (0.09) | 0.75 [0.50 to 1.13] | 137 (0.29) | 0.76 [0.61 to 0.95]* | 42 (0.09) | 0.73 [0.50 to 1.05] | |
| Duration (0%–20%) | 380 (0.81) | — | 98 (0.21) | — | 196 (0.42) | — | 85 (0.18) | — | |
| Duration (20%–40%) | 260 (0.56) | 0.88 [0.75 to 1.04] | 54 (0.12) | 0.77 [0.55 to 1.09] | 145 (0.31) | 0.91 [0.73 to 1.13] | 60 (0.13) | 1.00 [0.71 to 1.40] | |
| Duration (40%–60%) | 256 (0.55) | 0.90 [0.77 to 1.07] | 48 (0.1) | 0.72 [0.50 to 1.04] | 160 (0.34) | 1.04 [0.84 to 1.29] | 47 (0.1) | 0.82 [0.57 to 1.18] | |
| Duration (60%–80%) | 253 (0.54) | 0.84 [0.71 to 0.99]* | 45 (0.1) | 0.64 [0.44 to 0.94]* | 162 (0.35) | 1.00 [0.80 to 1.23] | 46 (0.1) | 0.75 [0.52 to 1.09] | |
| Duration (80%–100%) | 277 (0.59) | 0.84 [0.71 to 0.99]* | 48 (0.1) | 0.61 [0.42 to 0.89]** | 169 (0.36) | 0.96 [0.78 to 1.19] | 58 (0.12) | 0.82 [0.57 to 1.17] | |
* p < .05, ** p < .01, *** p < .001. Minimal model was adjusted for age, sex, and ethnicity. Full model was adjusted for age, sex, ethnicity, physical activity, socioeconomic status, social visits, smoking status, urbanicity, shift work, use of medication for cholesterol or hypertension. Higher SRI and duration quintiles represent more regular sleep and longer sleep duration, respectively.