Figure 4.

Prioritization scheme for selecting potent and selective bioactive fungal extracts. After an initial pool of 1,748 fungal extracts was tested, 71 of samples were identified as being more active than 25 μM metronidazole and exhibited sigmoidal concentration-response curves against T. vaginalis. The fungi responsible for generating the three active samples indicated in the chart by arrows were selected for bioassay-guided fractionation studies and the bioassay results for the resulting natural products are described in this communication.