Fig. 4.

a Example of annotated mitoses in the meningioma WSIs at different phases, including prophase, metaphase, anaphase-telophase, and atypical mitoses, bar=10$\mu m$. b Hotspot MC per 10 HPFs in each WSI using five methods of quantification, namely the proposed DFS algorithm, linear 10 HPFs (i.e., $10\times 1$ and $1\times 10$ arrangements), rectangular 10 HPFs (i.e., $5\times 2$ and $2\times 5$ arrangements), average MC per 10 HPFs, and maximum possible MC in 10 (not connected) HPFs.  For the MC distribution in randomly-sampled 10 HPFs: the box-whisker plot shows the percentiles and medians, and the magenta error bars demonstrate the average and 95% confidence intervals. For each WSI, the WHO grade assigned at the consensus conference was included. c Mitosis distribution in slide #11, and the spatial distribution of 10 HPFs with the proposed DFS algorithm (MC=19), linear 10 HPFs (MC=9 or 11), and rectangular 10 HPFs (MC=14), bar=1mm