TABLE 1.

Summary of the MANCTRA-1 Audit^*

	Investigated item	Compliance level (%)	Population
1	Optimal timing for the index CE-CT assessment is 72–96 hours after the onset of symptoms	6.1	Patients with severe acute biliary pancreatitis
2	Routine prophylactic antibiotics are not recommended for all patients with acute biliary pancreatitis (patients on antibiotics)	55.8 53.4 83.4 85.2	General cohort of patients with acute biliary pancreatitis Patients with mild acute biliary pancreatitis Patients with severe acute biliary pancreatitis Patients with infected pancreatic necrosis
3	Serum measurements of procalcitonin (PCT) may be valuable in predicting the risk of developing infected pancreatic necrosis	30.8 29.6	Patients with severe acute biliary pancreatitis Patients with infected pancreatic necrosis
4	Early (within 24 hours) oral feeding as tolerated, rather than keeping the patient nil per os, is recommended in patients with acute biliary pancreatitis	44.7 47.7	General cohort of patients with acute biliary pancreatitis Patients with mild acute biliary pancreatitis
5	EN is recommended to prevent gut failure and infectious complications in patients with acute biliary pancreatitis and inability to feed orally	33.2 39.3	Patients with severe acute biliary pancreatitis Patients with infected pancreatic necrosis
6	TPN should be avoided (patients on TPN)	36.2 34.4	Patients with severe acute biliary pancreatitis Patients with infected pancreatic necrosis
7	Early ERCP/ES should be performed in gallstone-induced acute biliary pancreatitis when complications of cholangitis and CBD obstruction occur	46.0 60.1 56.7	Patients with cholangitis Patients with CBD obstruction Patients with cholangitis and CBD obstruction
8	In patients with acute necrotizing pancreatitis, percutaneous or endoscopic drainage as the first-line treatment (step-up approach) delays the surgical treatment to a more favorable time or even results in complete resolution of infection in 25%–60% of patients, and it is recommended as the first line of treatment	33.7	Patients with acute necrotizing pancreatitis or infected pancreatic necrosis
9	Therapeutic intervention for infected pancreatic necrosis should be performed after 4 weeks of onset when the necrosis has been sufficiently walled off	37.2	Patients with infected pancreatic necrosis
10	Laparoscopic cholecystectomy during the index admission, rather than after discharge, is recommended in mild acute biliary pancreatitis	29.0	Patients with mild acute biliary pancreatitis

^*Podda et al. Pancreatology. 2022;22(7):902-916.¹¹

CBD indicates common bile duct; CE-CT, contrast enhanced CT scan; EN, enteral nutrition; ERCP/ES, endoscopic retrograde cholangiopancreatography/endoscopic sphincterotomy; PCT, procalcitonin; TPN, total parenteral nutrition.