TABLE 1.
Antibiotic spectrum of common UTI drugs tested with a small panel of laboratory strains and clinical UTI isolates according to EUCAST guidelines ISO20776-1:2019 d
| MIC [µg/mL] | NTX | NFT | FOS a , b | PIV a | CIP | TMP |
|---|---|---|---|---|---|---|
| E. coli ATCC25922 | 4 | 8 | 1 | 0.125 | 0.008 | 1 |
| E. coli MHH79495 c | 4 | 16 | 2 | 2 | 0.016 | >64 |
| E.coli MHH85227 c | 2 | 16 | 2 | 0.25 | 64 | >64 |
| K. pneumoniae DSM681 | 2–4 | 16–32 | 4 | 0.0625 | 0.004 | 0.5 |
| K. pneumoniae MHH84274 c | 4 | 64 | 8 | 8 | 1 | >64 |
| K. pneumoniae MHH84299 c | 4 | >64 | >64 | >64 | 64 | >64 |
| E. faecalis ATCC29212 | 16 | 8–16 | 32 | >64 | 1 | 0.25 |
| E. faecalis MHH83300 c | 8 | 8 | 64 | >64 | 0.5 | 0.125 |
| P. mirabilis DSM4479 | 16 | >64 | 64 | 16 | 0.03125 | 2 |
| P. mirabilis MHH82530 c | 16 | >64 | 32 | >64 | 8 | >64 |
| P. aeruginosa DSM27853 | 32 | >64 | 4 | >64 | 0.125 | >64 |
| P. aeruginosa MHH84389 c | 64 | >64 | 64 | >64 | 8 | >64 |
| S. aureus ATCC29213 | 2 | 16 | 2 | 64 | 0.25 | 2 |
| S. aureus MHH80207 c | 4 | 32 | 2 | >64 | >64 | 1 |
| S. aureus MHH85297 c | 8 | 16 | 64 | >64 | >64 | 0.5 |
a
Agar dilution method.
b
Supplemented with 25 mg/L glucose-6-phosphate.
c
Clinical isolate from Hannover Medical School (Germany), check SI for more details.
d
Bold numbers indicate non-susceptibility according to EUCAST (For NTX, E. coli breakpoints were used as approximation for all species).