TABLE 4.

Overview of NTX^R K. pneumoniae strains generated by adaptation ^a

MIC	NTX
	[µg/mL]	Fold change
KP681_WT	2	1
Kp_M1	32	16
Kp_M2	32	16
Kp_M3	16–32	8–16
Kp_M4	16	8
Kp_M5	32	16
Kp_M6	16	8
Kp_M7	16	8
Kp_M8	32	16
Kp_M9	32	16
Kp_M10	32	16
Kp_M11	32	16
Kp_M12	32	16
Kp_M13	16–32	8–16
Kp_M14	32	16
Kp_M15	32	16
Kp_M16	32	16
Kp_M17	32	16

^a MIC is displayed in µg/mL and normalized against K. pneumoniae DSM681 wildtype (fold change). Strains were grown in MHBII containing slowly increasing sub-inhibitory NTX concentration and isolated after 10 days of constant exposure (Kp_M1-17).