Fig 2.

Baseline reactivity to selected T. pallidum antigens. Antigens to which a significant difference in reactivity was detected in baseline sera (collected at diagnosis and prior to treatment) using stage (A, B), HIV status (C–E), and syphilis history (F–I) as covariates. In panels (A and B), the P-value indicates that there is a significant difference across the means of the four groups analyzed. Groups lean toward statistically significant differences in means (P < 0.1) if they do not share a letter. I, primary syphilis; II, secondary syphilis; EL, early latent; LL, late latent; U: latency of unknown duration; Pos, HIV-positive patients; Neg: HIV-negative patients; H, patients with history of syphilis; NH, patients with no history of syphilis. The horizontal bar indicates the mean absorbance value. Analyses in panels (A, B) were performed with 118 samples. Analyses in panels (C–E) were performed with 120 samples. Analysis in panels (F–I) was performed with 93 samples.