TABLE 4.
MICs before and after the intervention of the efflux pump inhibitor a
| Number | INH MICs (μg/mL) | INH + VP MICs (μg/mL) | P value | RIF MICs (μg/mL) | RIF + VP MICs (μg/mL) | P value |
|---|---|---|---|---|---|---|
| H37Rv | 0.0625 | 0.0312 | t = 7.000, P = 0.001 | 0.0625 | 0.0075 | t = 3.000, P = 0.030 |
| DS-1 | 0.0156 | 0.0075 | 0.0156 | 0.0075 | ||
| DS-2 | 0.0156 | 0.0075 | 0.0156 | 0.0075 | ||
| DS-3 | 0.0156 | 0.0075 | 0.0156 | 0.0075 | ||
| DS-4 | 0.0156 | 0.0075 | 0.0156 | 0.0075 | ||
| DS-5 | 0.0312 | 0.0075 | 0.0312 | 0.0156 | ||
| RR-1 | / | / | / | 32 | 16 | t = 3.500, P = 0.025 |
| RR-2 | / | / | 32 | 8 | ||
| RR-3 | / | / | 2 | 2 | ||
| RR-4 | / | / | 32 | 8 | ||
| RR-5 | / | / | 1 | 0.25 | ||
| HR-1 | 4 | 4 | / | / | / | / |
| HR-2 | 4 | 4 | / | / | ||
| HR-3 | 4 | 4 | / | / | ||
| HR-4 | 0.5 | 0.5 | / | / | ||
| HR-5 | 2 | 2 | / | / | ||
| HR-6 | 4 | 4 | / | / | ||
| HR-7 | 2 | 2 | / | / | ||
| HR-8 | 1 | 1 | / | / | ||
| HR-9 | 4 | 4 | / | / | ||
| HR-10 | 2 | 2 | / | / | ||
| HR-11 | 4 | 4 | / | / | ||
| HR-12 | 0.5 | 0.5 | / | / | ||
| HR-13 | 1 | 1 | / | / | ||
| HR-14 | 1 | 1 | / | / | ||
| HR-15 | 0.5 | 0.5 | / | / | ||
| HR-16 | 4 | 4 | / | / | ||
| HR-17 | 2 | 2 | / | / | ||
| HR-18 | 4 | 4 | / | / | ||
| MDR-1 | 2 | 2 | t = 2.715, P = 0.015 | 2 | 0.5 | t = 3.117, P = 0.006 |
| MDR-2 | 2 | 2 | 64 | 32 | ||
| MDR-3 | 2 | 2 | 256 | 128 | ||
| MDR-4 | 16 | 8 | 256 | 64 | ||
| MDR-5 | 2 | 1 | 256 | 64 | ||
| MDR-6 | 2 | 2 | 32 | 16 | ||
| MDR-7 | 2 | 2 | 16 | 16 | ||
| MDR-8 | 64 | 16 | 256 | 16 | ||
| MDR-9 | 32 | 16 | 128 | 64 | ||
| MDR-10 | 2 | 2 | 128 | 64 | ||
| MDR-11 | 16 | 8 | 64 | 64 | ||
| MDR-12 | 64 | 32 | 32 | 16 | ||
| MDR-13 | 0.5 | 0.25 | 16 | 4 | ||
| MDR-14 | 1 | 1 | 32 | 8 | ||
| MDR-15 | 1 | 1 | 1 | 1 | ||
| MDR-16 | 2 | 2 | 0.5 | 0.5 | ||
| MDR-17 | 2 | 2 | 8 | 4 | ||
| MDR-18 | 2 | 2 | 1 | 1 |
a
DS represents sensitive strains, RR represents RIF mono-resistant strains, HR represents INH mono-resistant strains, and MDR represents multi-drug resistant strains. "/" means that none of the 10 efflux pump genes is overexpressed. The MICs reduced after the intervention of the efflux pump inhibitor VP are highlighted in bold.