TABLE 2.
IC50 values of ENPP1 inhibitors that showed >30% ENPP1 inhibition
| Inhibitor | NCI | IC50 ENPP1 in μM (µg/mL) | IC50 Vero cells in μM (µg/mL) | MW in daltons |
|---|---|---|---|---|
| E-3 a | 14465 | 26.4 (10) | >264 (>100) | 379 |
| E-11 | 82907 | 245 (100) | >245 (>100) | 408 |
| E-12 a | 87015 | 41.1 (12.5) | >329 (>100) | 304 |
| E-13 | 89127 | 76 (25) | 182 (60) | 329 |
| E-14 | 95537 | 172 (75) | 115 (50) | 436 |
| E-15 | 99790 | 169 (60) | > 282 (>100) | 354 |
| E-17 a | 107121 | 15.6 (10) | 156 (100) | 642 |
| E-23 | 173694 | 50.1 (23) | 218 (100) | 459 |
| E-25 a | 210818 | 46.6 (12.5) | 186 (50) | 268 |
| E-27 a | 332061 | 16.3 (5.0) | >326 (>100) | 307 |
| E-37 a | 667746 | 44.6 (10) | >446 (>100) | 224 |
| E-54 a | 76479 | 13.6 (4.0) | 204 (60) | 293 |
| E-60 a | 99862 | 9.8 (4.0) | >245 (>100) | 410 |
| E-80 | 637507 | 186 (75) | >248 (>100) | 403 |
a
Compounds with ENPP1 IC50 values of 15 µg/mL or less.