Fig 4.

The combination of SMACm and DDX3i reduces the inducible HIV-1 reservoir in PBMC from PWH ex vivo. Ratio of PWH PBMCs/healthy CTV-stained PBMCs normalized to DMSO samples is displayed to check for cell survival of the compounds; the median is displayed (A). Logistic regression plot of the quantification of HIV-1-infected cells in PBMC from PWH after treatment with SMACm AZD5582, DDX3i FH1321, both, or DMSO control using TZM-BL cells (B). IUPM after treatment with the compounds for each participant; the median IUPM is displayed. Comparisons of each condition to control were made using a paired t test (C). Significant differences are indicated, **P < 0.01, ***P < 0.001.