Fig 7.

RNAi induced morphologic changes in ovaries of female S. mansoni. CLSM analysis of S. mansoni females and males treated for 15 days with different combinations of dsRNA (as indicated): (A, E, I, and M) Smgpcr20 and Smnpp26 dsRNA; (B, F, J, and N) Smgpcr20 and Smnpp40 dsRNA; (C, G, K, and O) a combination of the three gene-specific dsRNAs; (D, H, L, and P) control worms maintained under the same culture conditions but without dsRNA (n = 5 per experiment). O, ovary; imo, immature oocytes; mo, mature oocytes; sv, sperm vesicle; t, testes; vit, vitellarium; white stars indicate the ootype of females. Scale bars: 50 µm.