TABLE 1.
Susceptibility profiles of recombinant HSV-1 viruses to the TK-associated drugs tested in Vero cells and those tested in HEL cells
| Viruses | IC50 (mean ± SD µg/mL) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Vero cells | HEL cells | ||||||||
| ACV | PCV | GCV | ACV | PCV | GCV | BVDU | |||
| HSV-1_WT | 0.5 ± 0.1 a | 1.1 ± 0.2 a | 0.1 ± 0 a | 0.2 ± 0.1 a | 0.3 ± 0.1 a | 0.01 ± 0 a | 0.2 ± 0.06 a | ||
| HSV-1_HSV1TK | 0.6 ± 0.1 a | 0.9 ± 0.2 a | 0.1 ± 0.02 a | 0.2 ± 0.1 a | 0.3 ± 0.1 a | 0.01 ± 0 a | 0.2 ± 0.01 a | ||
| HSV-1_hBVTK | 4.7 ± 0.3 b | 13 ± 2.3 c | 4.1 ± 0.6 c | 12 ± 0.7 b | 5.1 ± 0.7 b | 2.4 ± 0.1 c | >40 c | ||
| HSV-1_mBVTK | 5.1 ± 0.3 b | 14 ± 1.2 c | 4.4 ± 0.7 c | 12 ± 1.7 b | 5.3 ± 0.3 b | 2.3 ± 0.2 c | >40 c | ||
| HSV-1_VZVTK | 3.8 ± 0.3 | 14 ± 1.8 | 4.0 ± 0.6 | 5.3 ± 0.2 | 2.2 ± 0.5 | 2.1 ± 0.03 | >40 | ||
a
Significantly different from HSV-1_hBVTK, HSV-1_mBVTK, and HSV-1_VZVTK (P < 0.01).
b
Significantly different from HSV-1_VZVTK (P<0.01). No significant difference between HSV-1_hBVTK and HSV-1_mBVTK.
c
Not significant from HSV-1_VZVTK. No significant difference between HSV-1_hBVTK and HSV-1_mBVTK.