Table 2: Top regions (p<10⁻⁵) in the TS GWAS meta-analysis (TS-EUROTRAIN and TSGWAS2).

The analysis performed on 6,133 cases, 13,565 controls on 1,955,677 variants using Han and Eskin’s random effects model (24). One variant was identified as genome-wide significant (p<5×10⁻⁸) while the second top hit reached a (p<10⁻⁷). Chromosome and region (based on hg19) are shown for index SNPs (LD-r²>0.1), as well as number of LD-associated markers in proximity (N). The reported nearest genes were determined by genomic location (±500 kb). MAF indicates the allelic frequency of the minor allele in the dataset. MAF EUR (1KG) indicates the frequency of the minor allele in the meta-analysis in the 1000 Genomes Project European samples.

SNP ID	Chr	P-value	OR	MAF	MAFEUR (1KG)	N	Location	KB	Nearest Genes
rs2453763	5	4.054E-08	0.83	0.358	0.347	25	chr5:92322427..92559372	236.946	NR2F1-AS1
rs10209244	2	6.156E-08	2.32	0.012	0.001	29	chr2:161422880..161676570	253.691	MIR4785, RBMS1
rs13401916	2	2.441E-07	2.08	0.014	0.003	13	chr2:161945103..162055548	110.446	LOC100996579, LOC101929512, PSMD14, TANK, TBR1
rs139469	22	9.997E-07	0.89	0.345	0.327	33	chr22:41451185..41627527	chr22:41451185..41627527	ACO2, CHADL, DNAJB7, EP300, EP300-AS1, L3MBTL2, MIR1281, MIR4766, MIR6889, PHF5A, RANGAP1, RBX1, SLC25A17, ST13, TEF, TOB2, XPNPEP3, ZC3H7B