Figure 1.

Forest plots of hazard ratios between chronic stress, personality traits, and major disease manifestations restricting to probands or relatives with PLN p.(Arg14del). All variables were analysed separately. Values are showed as hazard ratios, 95% confidence intervals and P-values. All analyses were adjusted for sex and educational level. Type D personality compromised two subscales on negative affectivity (tendency to experience negative emotions and social inhibition and tendency to inhibit emotion and behaviour in social situations). We used the mean-centred sum scores of both the negative affect (NAc) and social inhibition (SIc) subscales separately and the interaction as variable in the regression analyses.