Table 1:
Characteristics of hemodialysis sessions according to IDH definitions.
| Reduction-based (Fall40) | Nadir-based (Nadir90/100) | |||||||
|---|---|---|---|---|---|---|---|---|
| Variable | Total number | All sessions | Non-IDH (n = 97 397) | IDH (n = 13 003) | Standardized difference | Non-IDH (n = 98 947) | IDH (n = 11 453) | Standardized difference |
| Pre-HD 24 h. mean temp. (°C), mean (SD) | 110 400 | 25.2 (4.4) | 25.3 (4.3) | 24.1 (4.7) | 0.272 | 25.2 (4.4) | 24.7 (4.6) | 0.128 |
| Demographic data | ||||||||
| Age (years), mean (SD) | 110 400 | 62.9 (13.7) | 62.9 (13.7) | 63.3 (13.3) | 0.035 | 62.3 (13.6) | 68.6 (13.4) | 0.470 |
| Male, n (%) | 110 400 | 55 644 (50.4) | 47 837 (49.1) | 7807 (60.0) | 0.221 | 51 518 (52.1) | 4126 (36.0) | 0.327 |
| DM, n (%) | 110 400 | 48 180 (43.6) | 40 020 (41.1) | 8160 (62.8) | 0.444 | 42 179 (42.6) | 6001 (52.4) | 0.197 |
| HTN, n (%) | 110 400 | 83 010 (75.2) | 72 725 (74.7) | 10 285 (79.1) | 0.105 | 75 602 (76.4) | 7408 (64.7) | 0.259 |
| CAD, n (%) | 110 400 | 27 222 (24.7) | 24 380 (25.0) | 2842 (21.9) | 0.075 | 24 163 (24.4) | 3059 (26.7) | 0.052 |
| CCI, mean (SD) | 110 400 | 7.0 (2.8) | 7.0 (2.9) | 7.4 (2.6) | 0.146 | 6.9 (2.8) | 8.0 (2.7) | 0.407 |
| Hemodialysis records | ||||||||
| HD vintage (months), mean (SD) | 110 400 | 59 (53) | 60 (54) | 52 (46) | 0.163 | 59 (53) | 62 (58) | 0.050 |
| UF/DW (%), mean (SD) | 108 635 | 3.76 (1.80) | 3.61 (1.74) | 4.91 (1.85) | 0.726 | 3.66 (1.77) | 4.63 (1.83) | 0.539 |
| Pre-HD SBP (mmHg), mean (SD) | 110 395 | 136 (22) | 134 (21) | 155 (22) | 0.987 | 138 (21) | 121 (27) | 0.702 |
| Blood flow (mL/min), mean (SD) | 110 084 | 275 (36) | 275 (35) | 277 (38) | 0.040 | 277 (35) | 260 (34) | 0.483 |
| Dialysate flow (mL/min), mean (SD) | 110 379 | 564 (113) | 560 (110) | 597 (123) | 0.317 | 566 (114) | 547 (100) | 0.176 |
| Dialysate avg. temp. (°C), mean (SD) | 110 231 | 36.1 (0.4) | 36.1 (0.4) | 36.0 (0.4) | 0.244 | 36.1 (0.4) | 35.9 (0.4) | 0.448 |
| Conductivity (mEq/L), mean (SD) | 109 769 | 140.0 (0.6) | 140.0 (0.6) | 140.0 (0.7) | 0.031 | 140.0 (0.7) | 140.0 (0.5) | 0.033 |
| Dialysate calcium (mEq/L), n (%) | 110 384 | |||||||
| 1.8 | 1490 (1.3) | 1336 (1.4) | 154 (1.2) | 0.017 | 1428 (1.4) | 62 (0.5) | 0.091 | |
| 2.5 | 58 946 (53.4) | 52 021 (53.4) | 6925 (53.3) | 0.003 | 52 712 (53.3) | 6234 (54.4) | 0.023 | |
| 3.0 | 42 286 (38.3) | 37 230 (38.2) | 5056 (38.9) | 0.014 | 37 755 (38.2) | 4531 (39.6) | 0.029 | |
| 3.5 | 7662 (6.9) | 6794 (7.0) | 868 (6.7) | 0.012 | 7037 (7.1) | 625 (5.5) | 0.068 | |
| Hb, mean (SD) | 110 374 | 10.6 (1.0) | 10.6 (1.0) | 10.8 (1.0) | 0.188 | 10.6 (1.0) | 10.7 (1.0) | 0.150 |
| Antihypertensives and iron use, n (%) | 107 867 | |||||||
| ACEi/ARB | 27 204 (25.2) | 24 320 (25.0) | 2884 (22.2) | 0.066 | 26 216 (26.5) | 988 (8.6) | 0.483 | |
| Beta-blockers | 31 692 (29.4) | 27 943 (28.7) | 3749 (28.8) | 0.003 | 29 755 (30.1) | 1937 (16.9) | 0.314 | |
| Alpha-blockers | 11 912 (11.0) | 10 823 (11.1) | 1089 (8.4) | 0.092 | 11 530 (11.7) | 382 (3.3) | 0.320 | |
| Calcium channel blocker | 40 708 (37.7) | 37 099 (38.1) | 3609 (27.8) | 0.221 | 39 594 (40.0) | 1114 (9.7) | 0.748 | |
| Vasodilator | 8712 (8.1) | 7951 (8.2) | 761 (5.9) | 0.091 | 8289 (8.4) | 423 (3.7) | 0.198 | |
| IV_iron | 110 400 | 1569 (1.4) | 1392 (1.4) | 177 (1.4) | 0.000 | 1457 (1.5) | 112 (1.0) | 0.158 |
Data presented as mean (SD) in the continuous variables, and numbers (n) with the percentage (%) in categorical variables.
A standardized difference of <0.1 was considered a negligible difference between groups.
Temp., temperature; DM, diabetes mellitus; HTN, hypertension; CAD, coronary artery disease; CCI, Charlson Comorbidity Index; HD, hemodialysis; avg, average; Hb, hemoglobin; ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin-receptor blocker; IV_iron, intravenous iron infusion.