Table 1.

CRISPR/Cas9 interventional studies on Alzheimer’s disease

Study	Targeted gene	Outcomes
Pires et al.37	PSEN1	Production of a gene-corrected induced pluripotent stem cell line by substituting the point mutation with the wild-type sequence
Poon et al.38	PSEN1	Production of a gene-corrected induced pluripotent stem cell line by correcting for the single base pair mutation
Sun et al.39	PSEN1	Elimination of inherent γ-secretase background by disrupting PSEN1 genes in N2a cells
Konstantinidis et al.40	PSEN1	Reduction of extracellular Aβ42/40 ratios by disrupting the PSEN1 allele in human fibroblasts
Ortiz-Virumbrales et al.41	PSEN1	Correction of the electrophysiological deficit by rectifying the PSEN2 point mutation in basal forebrain cholinergic neurons generated from induced pluripotent stem cells
György et al.21	APP	Reduction of Aβ levels in fibroblasts after eliminating Swedish APP mutations
Guyon et al.42	APP	Decrease in the accumulation of Aβ peptide by introduction of the A673T mutation in HEK293T cells
Wadhwani et al.44	APOE4	Production of stem-cell-derived E3 neurons that are less susceptible to ionomycin-induced cytotoxicity by correcting E4 allele to the E3/E3 genotype