Table 2.

CRISPR/Cas9 interventional studies on Parkinson’s disease

Study	Targeted gene or protein	Outcome
Zhou et al.45	PINK1, PARK2	Generation of single or double gene-targeted porcine fetal fibroblasts
Kantor et al.46	SNCA	Reduction in SNCA levels of human-induced pluripotent stem cell (hiPSC)-derived dopaminergic neurons by targeted DNA methylation editing
Yoon et al.47	A53T-SNCA	Reduction of the overexpression of α-synuclein, reactive microgliosis, dopaminergic neurodegeneration, and parkinsonian motor symptoms by gene deletion of A53T-SNCA significantly
Inoue et al.48	p13 protein	Prevention of toxin-induced motor deficits and the loss of dopaminergic neurons in the substantia nigra of heterozygous p13 knockout mices