TABLE 2.
Echocardiography Cohort: Ventilatory and Cardiovascular Characteristics at Baseline and Postrandomization
| Baseline | Postrandomization | ||||
|---|---|---|---|---|---|
| ECCO2R Group (n = 13) | Usual care Group (n = 8) | ECCO2R Group (n = 13) | Usual care Group (n = 8) | p | |
| Respiratory characteristics | |||||
| Mode of ventilation, n (%) | |||||
| Mandatory | 10 (76.9) | 6 (75.0) | 11 (84.6) | 8 (100.0) | 0.51 |
| Mandatory and spontaneous breaths | 3 (23.1) | 1 (12.5) | 1 (7.7) | 0 (0.0) | |
| Spontaneous | 0 (0.0) | 1 (12.5) | 1 (7.7) | 0 (0.0) | |
| Adjunctive ventilatory therapies, n (%) | |||||
| Neuromuscular-blocking drugs | 10 (76.9) | 5 (62.5) | 7 (53.8) | 6 (75.0) | 0.33 |
| Prone positioning | 2 (15.4) | 2 (25.0) | 2 (15.4) | 2 (25.0) | 0.59 |
| Pao2/Fio2 ratio, median (IQR), mm Hga | 122.3 (117.0–137.3) | 123.8 (84.0–127.1) | 135.0 (123.0–197.3) | 159.0 (129.8–182.6) | 0.74 |
| Positive end-expiratory pressure, median (IQR), cm H2O | 10.0 (10.0–12.0) | 10.0 (9.0–12.0) | 10.0 (8.0–12.0) | 12.0 (11.0–13.0) | 0.09 |
| Tidal volume, median (IQR), mL/kg predicted body weight | 6.4 (5.9–6.8) | 5.7 (5.4–5.8) | 3.6 (3.1–4.2) | 5.2 (4.9–5.7) | 0.01 |
| Respiratory rate, mean (sd), breaths/min | 22.8 (6.5) | 24.1 (6.8) | 27.7 (5.7) | 27.9 (3.7) | 0.94 |
| Plateau pressure, mean (sd), cm H2O | 23.1 (4.3), n = 7 | 20.9 (2.9), n = 4 | 20.3 (6.1), n = 7 | 22.8 (1.8), n = 5 | 0.40 |
| Driving pressureb, mean (sd), cm H2O | 14.1 (3.7), n = 7 | 11.2 (2.2), n = 4 | 10.9 (5.1), n = 7 | 11.6 (2.0), n = 5 | 0.77 |
| Compliance, mean (sd) mL/cm H2O | 34.7 (26.7), n = 7 | 38.2 (3.6), n = 4 | 24.7 (13.1), n = 7 | 35.9 (5.5), n = 5 | 0.10 |
| Paco2, median (IQR), mm Hg | 55.5 (51.0–62.3) | 51.4 (46.5–58.1) | 62.3 (58.4–75.0) | 59.1 (52.5–63.4) | 0.33 |
| pH level, mean (sd) | 7.33 (0.09) | 7.32 (0.11) | 7.32 (0.08) | 7.31 (0.10) | 0.80 |
| Cardiovascular characteristics | |||||
| Heart rate, mean (sd) | 88.4 (26.8), n = 10 | 90.7 (17.7), n = 6 | 87.8 (20.2), n = 10 | 94.5 (14.6), n = 6 | 0.49 |
| Lowest mean arterial pressure, median (IQR), mm Hg | 62 (62–65) | 63.5 (60–65) | |||
| Noradenaline, n (%) | |||||
| Yes | 8 (61.5) | 7 (87.5) | |||
| No | 5 (38.5) | 1 (12.5) | |||
| Highest Noradrenaline, median (IQR), µg/kg/min | 0.07 (0–0.15) | 0.17 (0.08–0.48) | |||
| Vasopressin, n (%) | |||||
| Yes | 0 (0.0) | 1 (12.5) | |||
| No | 13 (100.0) | 7 (87.5) | |||
| Milrinone, n (%) | |||||
| Yes | 0 (0.0) | 1 (12.5) | |||
| No | 13 (100.0) | 7 (87.5) | |||
IQR = interquartile range.
a
Second qualifying Pao2/Fio2 ratio.
b
Driving pressure = plateau pressure—positive end-expiratory pressure.
p values from t-test where mean (sd) presented or Mann-Whitney U test where median (IQR) presented or chi-square for categorical data.