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. 2023 Nov 16;52(1):49–58. doi: 10.1093/nar/gkad1015

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Synthesis and reactivity of compound 1. (A) Synthesis of 1 is performed in a single step from 2-phthalimidoethanesulfonyl chloride. (B) Internal amino-modification of ONs is done by replacing the regular oxidation step for treatment with 1 during SPOS. (C) Modification yield was evaluated by HPLC analysis after SPOS of a DNA, 2′OMe or 2′F modified 8-mer ON with a single amino-modification made by treatment with 1. Data represents mean and standard deviation (SD) of n = 3 replicated syntheses.