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Regioisomeric GLP1–siRNA conjugates. (A) Workflow for generating conjugates. Sense strands were amino-modified at different positions in the backbone using 1 during SPOS. The pH-controlled linker 2 was used to conjugate the sense strands to GLP1 followed by hybridization with the corresponding antisense strand to form GLP1–siRNA conjugates. (B) List of synthesized strands and chemical structure of modification.
