. Author manuscript; available in PMC: 2024 Jan 11.

Published in final edited form as: Curr Ophthalmol Rep. 2022 Oct 20;10(4):188–197. doi: 10.1007/s40135-022-00295-3

Table 1.

Ocular surface ion transporters

	Gene	Transporter name	Location	Putative function
1	TRP	TRPV1, TRPV2, TRPV4, TRPA1, TRPM8	Apical	Non-selective cation channel
	ASIC	ASIC		Acid-sensing cation channel
2	SLC8A1	NCX	Apical	Na⁺/Ca²⁺ exchanger
3	SLC10A6	SOAT	Apical	Na⁺-dependent organic anion transporter
4	ATP2B1/ATP2C1	Mg²⁺/Ca²⁺-ATPase	Apical	ATP-activated transport of Ca²⁺ and Mg²⁺
5	CFTR	CFTR	Apical	cAMP-activated Cl⁻ channel
	CLCN2	Clc-2
6	P2RY2	P2Y2	Apical	Purinergic GPCR, indirectly activates CaCC via increasing intracellular Ca²⁺
7	CLCA	CaCC	Apical	Ca²⁺-activated Cl⁻ channel
8	SCNN1A/G/B	ENaC	Apical	Amiloride-sensitive Na⁺ channel
9	KCN	K_v	Apical	Voltage-gated K⁺ channel
10	ATP12A	H⁺/K⁺-ATPase	Apical	ATP-activated exchange of H⁺/K⁺
11	AQP5	AQP-5	Apical/Basolateral	Water channel protein^*
12	SLC12A1	NKCC	Basolateral	Electroneutral Na⁺/K⁺/2Cl⁻ cotransporter
13	ATP1A1/ATP1B1	Na⁺/K⁺-ATPase	Basolateral	ATP-activated exchange of 3 Na⁺/2 K⁺
14	SLC9A1	NHE	Basolateral	Na⁺/H⁺ exchanger
15	SLC12A6	KCC	Basolateral	K⁺/Cl⁻ cotransporter
16	SLC4	CBE	Basolateral	Cl⁻/HCO₃⁻ exchanger
17	KCNQ	K_v7	Basolateral	cAMP-activated K⁺ channel
18	KCNN	KCa	Basolateral	Ca²⁺-activated K⁺ channel

Not an ion transporter, but critical for movement of water