|
Endothelial cells
|
VWF, PECAM1, CDH5
|
Pan-EC markers |
| EC1–Arteriolar |
NOTCH4, SOX17, HEY1
|
Arterial EC differentiation |
|
EFNB2, SEMA3G
|
Angiogenesis |
|
NEBL, TSPAN2
|
Cytoskeleton organization |
|
GJA5
|
Gap junction |
| EC2–Capillary |
CA4, FMO2, RBP7
|
pH and redox homeostasis |
|
CD300LG
|
Leukocyte binding/rolling |
|
CD36
|
Fatty acid uptake |
|
RGCC
|
Cell cycle regulation |
| EC3–Venous |
NR2F2
|
Venous EC differentiation |
|
PLVAP, AQP1
|
Permeability |
|
ACKR1
|
Chemokine transcytosis |
|
ICAM1, VCAM1, SELE, SELP
|
Leukocyte adhesion |
| EC4–Valvular |
FOXC2
|
Valvular EC differentiation |
|
CRTAC1, EFEMP1, POSTN, HAPLN3
|
Extracellular matrix (ECM) |
|
BMP2, GDF7
|
ECM synthesis |
|
SERPINE1, PTGS2
|
Hemostasis |
| EC5–Lymphatic |
FOXC2, NR2F1, PROX1
|
Lymphatic EC differentiation |
|
LYVE1, PDPN, RELN
|
Leukocyte trafficking |
|
Smooth muscle cells
|
ACTA2, SRF, MRTFA, MRTFB
|
Pan-SMC/pericyte markers |
| SMC1–Desminhigh
|
MYH11, CALD1, TAGLN
|
SMC contraction |
|
DES, CNN1, MYLK, ADRA2C
|
Regulation of contraction |
|
FN1, COL1A2, COL3A1, VCAN
|
ECM |
|
ITGA5, ITGA8
|
ECM binding |
| SMC2–Desminlow
|
MYH11, CALD1, TAGLN
|
SMC contraction |
|
PLN, SORBS2, NET1, RERGL, HRH2, ADRA2A
|
Regulation of contraction |
|
NDUFA4L2
|
Low-oxygen sensing |
|
PGF
|
Angiogenesis; inflammation |
| SMC3–Pericyte |
CD36, APOE, STEAP4, FABP4
|
Fatty acid uptake/metabolism |
|
CYGB
|
Oxygen diffusion |
|
EDNRB
|
Vasoreactivity |
|
THY1
|
Stemness; leukocyte infiltration |
|
Fibroblasts
|
PDGFRA, LUM, C1R, DCN, THY1
|
Pan-fibroblast markers |
| Fib1–Activated |
COL1A1, COL1A2, COL3A1, BGN, POSTN, FN1
|
ECM; cell migration |
|
ACTA2, TAGLN, NREP
|
Myofibroblastic transition |
|
NDUFA4L2
|
Low-oxygen sensing |
|
F2R
|
Hemostasis |
|
ITGA10
|
ECM binding |
| Fib2–Maintenance |
COL1A1, COL1A2, COL3A1, BGN
|
ECM |
|
NDUFA4L2
|
Low-oxygen sensing |
| Fib3–Secretory |
C1S, C3, CFD
|
Complement factors |
|
CD34, CXCL14, SFRP1, SVEP1
|
Regulation of angiogenesis |
|
APOD, IGF1, IGFBP5, PLA2G2A, PLPP3, GPX3, MGST1
|
Lipid metabolism |
|
SCARA5
|
Ferritin-iron uptake; adipocytic commitment |
|
Monocyte/macrophages
|
CD163, CD14, FCGR3A, MRC1
|
Pan-mo/mφ markers |
| Mo/Mφ1–IL1B+
|
IL1B, NLRP3, EREG, CCL20, TNF
|
Inflammation |
| Mo/Mφ2–IL1B-
|
C1QA, C1QB, C1QC, VSIG4 |
Inflammation resolution |
| SELENOP |
Redox homeostasis |
| FOLR2 |
Folate uptake |
