Table 5.
Genotype frequencies and genetic models for PCOS and non-PCOS women in all 5 SNPs present in CALP10 gene.
| Gene (rs number) | Genotypes | PCOS (n=90) | Non-PCOS (n=90) | OR (95%CI) and P Value |
|---|---|---|---|---|
| CALP10 (rs3842570) | II (Wild type) | 14 (15.6%) | 28 (31.1%) | 1.00 |
| ID (Heterozygous Mutant) | 40 (44.4%) | 38 (42.2%) | OR-2.11 (0.96-4.59); p=0.02 | |
| DD (Homozygous Mutant) | 36 (40.0%) | 24 (26.7%) | OR-1.71 (0.78-3.74); p=0.17 | |
| ID+DD Vs II (Dominant Model) | 76 (84.4%) | 62 (68.9%) | OR-2.45 (1.18-5.05); p=0.01 | |
| DD+II Vs ID (SD/CD) | 50 (55.6%) | 52 (57.8%) | OR-0.91 (0.50-1.64); p=0.76 | |
| DD Vs ID+II (Recessive Model) | 36 (40.0%) | 24 (26.7%) | OR-1.83 (0.97-3.44); p=0.057 | |
| CALP10 (rs3792267) | GG (Wild type) | 60 (66.8%) | 69 (76.7%) | 1.00 |
| GA (Heterozygous Mutant) | 24 (26.7%) | 19 (21.1%) | OR-1.45 (0.72-2.91); p=0.29 | |
| AA (Homozygous Mutant) | 06 (6.7%) | 02 (2.2%) | OR-3.45 (0.67-17.74); p=0.11 | |
| GA+AA Vs GG (Dominant) | 30 (33.4%) | 21 (23.3%) | OR-1.64 (0.82-3.16); p=0.13 | |
| AA+GG Vs GA (SD/CD) | 66 (73.3%) | 71 (78.9%) | OR-0.73 (0.36-1.46); p=0.38 | |
| AA Vs GA+GG (Recessive) | 06 (6.7%) | 02 (2.2%) | OR-3.14 (0.61-16.01); p=0.14 | |
| CALP10 (rs2975760) | TT (Wild type) | 55 (61.1%) | 71 (78.9%) | 1.00 |
| TC (Heterozygous Mutant) | 26 (28.9%) | 17 (18.9%) | OR-1.97 (0.97-3.99); p=0.056 | |
| CC (Homozygous Mutant) | 09 (10%) | 02 (2.2%) | OR-5.81 (1.21-27.98); p=0.01 | |
| TC+CC Vs TT (Dominant Model) | 35 (38.9%) | 19 (21.1%) | OR-2.37 (1.23-4.61); p=0.009 | |
| CC+TT Vs TC (SD/CD) | 64 (71.1%) | 73 (81.1%) | OR-0.57 (0.28-1.15); p=0.11 | |
| CC Vs TC+TT (Recessive Model) | 09 (10%) | 02 (2.2%) | OR-4.88 (1.02-23.3); p=0.02 | |
| CALP10 (rs2975762) | GG (Wild type) | 29 (32.2%) | 63 (70.0%) | 1.00 |
| GA (Heterozygous Mutant) | 25 (27.8%) | 12 (13.3%) | OR-4.52 (2.01-10.24); p=0.0001 | |
| AA (Homozygous Mutant) | 36 (40.0%) | 15 (16.7%) | OR-5.21 (2.47-10.98); p<0.0001 | |
| GA+AA Vs GG(Dominant) | 61 (67.8%) | 27 (30.0%) | OR-4.91 (2.61-9.23); p<0.0001 | |
| AA+GG Vs GA (SD/CD) | 65 (72.2%) | 78 (86.7%) | OR-0.41 (0.18-0.86); p=0.01 | |
| AA Vs GA+GG (Recessive) | 36 (40.0%) | 15 (16.7%) | OR-3.33 (1.67-6.68); p=0.0005 | |
| CALP10 (rs5030952) | CC (Wild type) | 68 (75.5%) | 85 (94.5%) | 1.00 |
| CT (Heterozygous Mutant) | 15 (16.7%) | 04 (4.4%) | OR-4.68 (1.48-14.78); p=0.004 | |
| TT (Homozygous Mutant) | 07 (7.8%) | 01 (1.1%) | OR-8.75 (1.05-72.85); p=0.01 | |
| CT+TT Vs CC (Dominant Model) | 22 (24.4%) | 05 (5.6%) | OR-5.51 (1.98-15.28); p=0.0003 | |
| TT+CC Vs CT (SD/CD) | 75 (83.3%) | 86 (95.6%) | OR-0.69 (0.18-2.69); p=0.59 | |
| TT Vs CT+CC (Recessive Model) | 07 (7.8%) | 01 (1.1%) | OR-7.51 (0.90-62.31); p=0.03 |
SD-Semi Dominant/CD-co-dominant models; OR-Odds Ratio and 95%CI, Confidence Intervals.