Table 3.

Utility of HTS-TCR in skin: key points.

T-cell clonality tests are now an essential component of the diagnostic toolkit for CTCL

Immunosequencing precisely identifies and quantifies the genetic sequence of TCR CDR3 of malignant clones

Increased sensitivity and specificity of HTS-TCR compared to PCR aids in diagnosis of early-stage MF

HTS-TCR can provide TCF, a measure that has prognostic value

HTS-TCR can be used to monitor the treatment response by tracking malignant T-cell clones in the skin and blood after treatment

HTS-TCR can help distinguish between disease recurrence, treatment related cutaneous adverse events, and co-existing malignancies