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. 2023 Dec 22;34:138–149. doi: 10.1016/j.bioactmat.2023.12.010

Fig. 4.

Fig. 4

Stability and lipid composition analysis of M-Exos and H-Exos. (A) Bio-distribution of Cy5.5-labeled M-Exos. After oral administration of saline, Cyanine 5.5, Cyanine 5.5-labeled H-Exos, and Cyanine 5.5-labeled M-Exos to 8-week-old female BALB/c, radiant efficiency was measured at 8 h, 24 h, 48 h, or 72 h. (B) Tissue images of Cy3-labeled siRNA absorbed into the stomach, small intestine, and colon. Green (Cyanine 3-labeled TNF-α siRNA). (C) Lipidomics analysis of M-Exos compared to H-Exos. Data are mean ± SD (n = 4). (D) Lipid composition ratio constituting H-Exos and M-Exos.