Table 1.
Sample Characteristics by APOE Status
| APOE2+ | APOE3 | APOE4+ | P-value | |
|---|---|---|---|---|
| N | 746 | 3,379 | 1,233 | |
| Age, M (SD) | 70.33 (4.03) | 70.17 (3.84) | 69.98 (3.72) | 0.12 |
| Body Mass Index (kg/m2), M (SD) | 28.42 (5.69) | 28.37 (5.43) | 28.25 (6.10) | 0.78 |
| Education, N (%) | 0.76 | |||
| <High school | 36 (4.8) | 201 (5.9) | 66 (5.4) | |
| High school | 265 (35.5) | 1,132 (33.5) | 434 (35.2) | |
| College | 282 (37.8) | 1,266 (37.5) | 454 (36.8) | |
| Postgraduate | 163 (21.8) | 780 (23.1) | 279 (22.6) | |
| Smoking, N (%) | 0.98 | |||
| Never | 403 (54.0) | 1,822 (53.9) | 654 (53.0) | |
| Former | 296 (39.7) | 1,336 (39.5) | 496 (40.2) | |
| Current | 47 (6.3) | 221 (6.5) | 83 (6.7) | |
| Alcohol servings per week, M (SD) | 2.43 (5.20) | 2.65 (5.50) | 2.69 (5.40) | 0.54 |
| Serum blood lipids (mg/dL), M (SD) | ||||
| LDL cholesterol | 134.34 (32.45) | 154.31 (34.95) | 159.74 (35.78) | <0.001 |
| HDL cholesterol | 55.25 (12.71) | 53.67 (12.25) | 52.30 (12.43) | <0.001 |
| Non-HDL cholesterol | 162.20 (37.95) | 182.16 (39.07) | 188.55 (38.83) | <0.001 |
| Total cholesterol | 217.45 (36.17) | 235.83 (39.01) | 240.86 (38.55) | <0.001 |
| Remnant cholesterol | 27.86 (12.63) | 27.85 (13.39) | 28.82 (13.36) | 0.08 |
| Triglycerides | 139.71 (63.13) | 139.79 (66.92) | 144.59 (66.84) | 0.08 |
| LDL/HDL ratio | 2.57 (0.93) | 3.01 (0.92) | 3.21 (1.00) | <0.001 |
| Total/HDL ratio | 4.14 (1.18) | 4.59 (1.18) | 4.83 (1.26) | <0.001 |
| Total energy intake (kcal/day), M (SD) | 1,611.09 (677.73) | 1,582.89 (648.84) | 1,583.64 (658.81) | 0.56 |
| Dietary carbohydrate (g/day), M (SD) | 193.67 (79.18) | 192.89 (78.63) | 196.67 (81.84) | 0.36 |
| Dietary protein (g/day), M (SD) | 67.36 (30.68) | 66.37 (29.20) | 66.23 (30.41) | 0.67 |
| Dietary total fat (g/day), M (SD) | 62.27 (34.61) | 59.55 (32.93) | 58.12 (32.55) | 0.03 |
| Saturated fat | 21.38 (12.50) | 20.29 (12.00) | 19.78 (12.01) | 0.02 |
| Monounsaturated fat | 23.53 (13.36) | 22.49 (12.68) | 21.94 (12.40) | 0.03 |
| Polyunsaturated fat | 12.51 (7.44) | 12.12 (6.98) | 11.85 (6.82) | 0.13 |
| Trans fat | 4.47 (3.10) | 4.28 (3.02) | 4.26 (2.99) | 0.27 |
| Dietary cholesterol (g/day), M (SD) | 227.49 (145.02) | 214.49 (133.12) | 204.65 (128.00) | 0.001 |
| Probable Dementia, N (%) | 59 (7.9) | 321 (9.5) | 208 (16.9) | <0.001 |
| Mild Cognitive Impairment, N (%) | 49 (6.6) | 211 (6.2) | 87 (7.1) | 0.21 |
| Cholesterol-lowering medication, N (%) | 61 (8.2) | 418 (12.4) | 186 (15.1) | 0.003 |
| HMG CoA reductase inhibitor | 43 (5.8) | 365 (10.8) | 164 (13.3) | |
| Bile sequestrant | 3 (0.4) | 17 (0.5) | 9 (0.7) | |
| Fibric acid derivative | 14 (1.9) | 22 (0.7) | 12 (1.0) | |
| Unspecified antihyperlipidemic | 0 (0) | 1 (0.0) | 0 (0) | |
| Combination antihyperlipidemic | 1 (0.1) | 13 (0.4) | 1 (0.1) |
SI conversion factor: To convert cholesterol levels to mmol/L, multiply values by 0.0259. To convert triglyceride levels to mmol/L, multiply values by 0.0113.
Abbreviations: HDL = high-density lipoprotein; LDL = low-density lipoprotein.