Table 2.
Interactions of Dietary Cholesterol and Fat with APOE Status in Relation to Blood Lipids
|
Blood Lipid |
APOE Group (ref=APOE3) |
C x APOE Estimate (95% CI) |
SF x APOE Estimate (95% CI) |
TF x APOE Estimate (95% CI) |
MF x APOE Estimate (95% CI) |
PF x APOE Estimate (95% CI) |
|---|---|---|---|---|---|---|
| LDL Cholesterol | APOE2+ | 0.01 (−0.02, 0.04) | 0.29 (−0.37, 0.95) | 0.33 (−1.42, 2.09) | −0.33 (−1.35, 0.69) | −0.30 (−1.26, 0.66) |
| APOE4+ | 0.03 (0.002, 0.06)* | 0.23 (−0.40, 0.85) | −0.23 (−1.81, 1.34) | −0.55 (−1.53, 0.43) | 0.25 (−0.63, 1.12) | |
| HDL Cholesterol | APOE2+ | −0.01 (−0.02, 0.002) | −0.20 (−0.41, 0.02) | −0.63 (−1.20, −0.06)* | 0.50 (0.17, 0.84)† | −0.19 (−0.50, 0.12) |
| APOE4+ | −0.01 (−0.02, 0.0001) | −0.05 (−0.26, 0.15) | 0.09 (−0.42, 0.60) | 0.13 (−0.19, 0.45) | −0.01 (−0.29, 0.28) | |
| Non−HDL Cholesterol | APOE2+ | 0.02 (−0.02, 0.05) | 0.39 (−0.34, 1.13) | 0.71 (−1.25, 2.67) | −0.62 (−1.76, 0.52) | −0.24 (−1.32, 0.84) |
| APOE4+ | 0.04 (0.01, 0.07)* | 0.33 (−0.37, 1.03) | −0.43 (−2.19, 1.33) | −0.72 (−1.81, 0.38) | 0.27 (−0.71, 1.25) | |
| Total Cholesterol | APOE2+ | 0.01 (−0.03, 0.04) | 0.20 (−0.53, 0.93) | 0.07 (−1.87, 2.02) | −0.12 (−1.24, 1.01) | −0.43 (−1.50, 0.64) |
| APOE4+ | 0.03 (−0.003, 0.06) | 0.28 (−0.42, 0.97) | −0.34 (−2.09, 1.41) | −0.59 (−1.68, 0.50) | 0.27 (−0.71, 1.24) | |
| LDL/HDL Ratio | APOE2+ | 0.0004 (−0.0004, 0.001) | 0.01 (−0.004, 0.03) | 0.02 (−0.02, 0.07) | −0.02 (−0.05, 0.004) | −0.004 (−0.03, 0.02) |
| APOE4+ | 0.001 (0.0001, 0.002)* | 0.01 (−0.01, 0.03) | −0.02 (−0.06, 0.03) | −0.01 (−0.04, 0.01) | 0.001 (−0.02, 0.02) | |
| Total/HDL Ratio | APOE2+ | 0.001 (−0.001, 0.002) | 0.02 (−0.004, 0.04) | 0.04 (−0.02, 0.10) | −0.03 (−0.07, 0.002) | −0.003 (−0.04, 0.03) |
| APOE4+ | 0.001 (0.0001, 0.002)* | 0.01 (−0.01, 0.03) | −0.02 (−0.07, 0.03) | −0.02 (−0.05, 0.01) | −0.001 (−0.03, 0.03) | |
| Remnant Cholesterol | APOE2+ | 0.01 (−0.005, 0.02) | 0.11 (−0.13, 0.35) | 0.37 (−0.27, 1.01) | −0.29 (−0.66, 0.08) | 0.06 (−0.29, 0.41) |
| APOE4+ | 0.01 (−0.003, 0.02) | 0.10 (−0.13, 0.33) | −0.20 (−0.77, 0.37) | −0.17 (−0.53, 0.19) | 0.02 (−0.30, 0.34) | |
| Triglycerides | APOE2+ | 0.03 (−0.03, 0.09) | 0.52 (−0.68, 1.71) | 1.83 (−1.37, 5.02) | −1.37 (−3.23, 0.48) | 0.24 (−1.51, 2.00) |
| APOE4+ | 0.04 (−0.01, 0.09) | 0.49 (−0.65, 1.63) | −0.95 (−3.82, 1.92) | −0.82 (−2.61, 0.97) | 0.10 (−1.50, 1.70) |
*
p<0.05,
†
p<0.01.
SI conversion factor: To convert cholesterol levels to mmol/L, multiply values by 0.0259. To convert triglyceride levels to mmol/L, multiply values by 0.0113.
Abbreviations: C = dietary cholesterol; CI = confidence interval; HDL = high-density lipoprotein; LDL = low-density lipoprotein; MF = dietary monounsaturated fat; PF = dietary polyunsaturated fat; ref = reference group; SF = dietary saturated fat; TF = dietary trans fat; x = interaction between dietary variable and APOE.