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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: Alzheimers Dement. 2023 Jul 12;19(12):5742–5754. doi: 10.1002/alz.13358

Table 5.

Odds Ratios for Dementia per Unit (mg/dL) Increase in Blood Lipids using APOE4 Risk Score-Predicted Levels of Blood Lipids

Probable Dementia Cognitive Impairment
Blood Lipid OR (95% CI) P-value OR (95% CI) P-value
LDL Cholesterol 1.05 (1.04, 1.06) <0.001 1.04 (1.03, 1.05) <0.001
HDL Cholesterol 0.70 (0.63, 0.77) <0.001 0.76 (0.70, 0.82) <0.001
Non-HDL Cholesterol 1.05 (1.03, 1.06) <0.001 1.03 (1.02, 1.05) <0.001
Total Cholesterol 1.05 (1.04, 1.07) <0.001 1.04 (1.03, 1.05) <0.001
Remnant Cholesterol 3.13 (2.31, 4.24) <0.001 2.38 (1.85, 3.06) <0.001
Triglycerides 1.25 (1.18, 1.33) <0.001 1.19 (1.13, 1.25) <0.001

Abbreviations: CI = confidence interval; HDL = high-density lipoprotein; LDL = low-density lipoprotein; OR = odds ratio.