Table 2.
Comparison of UKY and ABC-DS cohort demographics and plasma biomarker levels.
| Characteristic | ABC-DS N = 2391 | UKY, N = 851 | Overall, N = 3241 | p-value2 |
|---|---|---|---|---|
| Age | 44.58 (9.74) | 41.47 (10.35) | 43.76 (9.98) | 0.016 |
| Sex | 0.017 | |||
| Female | 113 (47%) | 53 (62%) | 166 (51%) | |
| Males | 126 (53%) | 32 (38%) | 158 (49%) | |
| Level of Intellectual Disability | 0.9 | |||
| Borderline/Mild | 129 (54%) | 45 (53%) | 174 (54%) | |
| Moderate/Severe | 110 (46%) | 40 (47%) | 150 (46%) | |
| Consensus Diagnosis | 0.3 | |||
| No Dementia | 169 (71%) | 51 (60%) | 220 (68%) | |
| Other/Uncertain | 16 (6.7%) | 8 (9.4%) | 24 (7.4%) | |
| Possible | 34 (14%) | 15 (18%) | 49 (15%) | |
| Probable | 20 (8.4%) | 11 (13%) | 31 (9.6%) | |
| DLD - Total | 13.13 (14.12) | 17.28 (14.03) | 14.22 (14.19) | 0.007 |
| DLD - Cognitive | 6.77 (8.59) | 8.61 (8.41) | 7.25 (8.56) | 0.047 |
| DLD - Social | 6.36 (6.82) | 8.67 (6.76) | 6.97 (6.87) | 0.001 |
| Plasma NT1-tau (pg/ml) | 4.66 (2.05) | 3.13 (1.56) | 4.26 (2.04) | <0.001 |
| Plasma Aβ37 (pg/ml) | 45.73 (11.51) | 47.21 (17.30) | 46.12 (13.26) | >0.9 |
| Plasma Aβ40 (pg/ml) | 955.39 (454.30) | 1,620.12 (981.71) | 1,129.78 (698.92) | <0.001 |
| Plasma Aβ42 (pg/ml) | 77.23 (17.48) | 87.67 (20.51) | 79.97 (18.86) | <0.001 |
| Plasma Aβ42:Aβ40 | 0.09 (0.04) | 0.07 (0.03) | 0.09 (0.04) | <0.001 |
| Plasma Aβ37:Aβ42 | 0.62 (0.21) | 0.54 (0.15) | 0.60 (0.20) | <0.001 |
| Plasma Aβ37:Aβ40 | 0.06 (0.03) | 0.03 (0.01) | 0.05 (0.02) | <0.001 |
1
Mean (SD); n (%)
2
Wilcoxon rank sum test; Pearson’s Chi-squared test