Table 2.
Differentially expressed WNT pathway genes in day 10 PANX1−/− organoids.
| WNT up | Fold increase | Role in neurodevelopment | Refs |
|---|---|---|---|
| WNT8A | 5.49 |
• Wnt8 inhibits BMP4 expression, allowing neural induction from ectoderm • Promotes synaptogenesis via LRP6 |
[77, 78] |
| DKK4 | 3.61 | • Associated with schizophrenia | [79] |
| FZD10 | 2.52 | • Plays a role in neural tube patterning | [80] |
| PRKG2 | 2.49 | • PRKG2-deficient mice exhibit restricted growth and deficits in learning and memory, similar to human patients | [81] |
| RSPO4 | 2.23 |
| WNT down | Fold decrease | Role in neurodevelopment | Refs |
|---|---|---|---|
| RSPO2 | 14.47 | • Promotes midbrain dopaminergic neurogenesis and differentiation | [23] |
| WNT2B | 4.91 | • Associated with bipolar disorder | [82] |
| WNT7A | 4.72 |
• Stimulates neural stem cell proliferation and promotes neuronal differentiation • Associated with bipolar disorder |
[82–84] |
| RSPO3 | 4.22 | ||
| RSPO1 | 2.99 | ||
| SOST | 2.34 | ||
| WNT7B | 2.26 | • Promotes dendrite development in mouse hippocampal neurons | [85, 86] |
| WNT8B | 2.15 | • Expression restricted to the developing forebrain | [87] |
| WNT3A | 2.01 |