Table 1.
ENIGMA MDD participating cohorts in the study. Each cohort is presented with number of total subjects, number of patients with major depressive disorder (MDD) and healthy controls (HC), as well as their mean age (in years) and sex (number and % of females).
| Cohort | Number of subjects | Age mean (SD) | Number of females (%) |
|---|---|---|---|
| AFFDIS | |||
| Total | 79 | 39.75 (14.67) | 36 (46) |
| HC | 46 | 39.87 (14.29) | 22 (48) |
| MDD | 33 | 39.58 (15.18) | 14 (42) |
| Pharmo (AMC) | |||
| Total | 51 | 29.37 (4.64) | 51 (100) |
| HC | 0 | N/A | N/A |
| MDD | 51 | 29.37 (4.64) | 51 (100) |
| Barcelona-StPau | |||
| Total | 94 | 46.66 (7.81) | 72 (77) |
| HC | 32 | 46.03 (8.00) | 23 (72) |
| MDD | 62 | 46.98 (7.68) | 49 (79) |
| CARDIFF | |||
| Total | 40 | 46.55 (11.74) | 27 (68) |
| HC | 0 | N/A | N/A |
| MDD | 40 | 46.55 (11.74) | 27 (68) |
| CSAN | |||
| Total | 109 | 34.70 (12.88) | 74 (68) |
| HC | 49 | 33.20 (12.07) | 34 (69) |
| MDD | 60 | 35.92 (13.38) | 40 (67) |
| Calgary | |||
| Total | 107 | 17.03 (4.12) | 60 (56) |
| HC | 52 | 15.81 (5.03) | 29 (56) |
| MDD | 55 | 18.19 (2.51) | 31 (56) |
| DCHS | |||
| Total | 79 | 30.91 (6.71) | 79 (100) |
| HC | 61 | 31.49 (6.82) | 61 (100) |
| MDD | 18 | 28.94 (5.89) | 18 (100) |
| ETPB | |||
| Total | 60 | 35.03 (9.86) | 36 (60) |
| HC | 26 | 33.88 (10.22) | 16 (62) |
| MDD | 34 | 35.91 (9.48) | 20 (59) |
| Episca (Leiden) | |||
| Total | 49 | 15.00 (1.54) | 42 (86) |
| HC | 30 | 14.73 (1.53) | 26 (87) |
| MDD | 19 | 15.42(1.46) | 16 (84) |
| FIDMAG | |||
| Total | 69 | 47.22 (12.29) | 44 (64) |
| HC | 34 | 45.94 (11.49) | 22 (65) |
| MDD | 35 | 48.46 (12.90) | 22 (63) |
| Groningen | |||
| Total | 41 | 44.27 (13.67) | 30 (73) |
| HC | 21 | 44.05 (13.96) | 16 (76) |
| MDD | 20 | 44.50 (13.34) | 14 (70) |
| Houston | |||
| Total | 290 | 28.72 (16.30) | 169 (58) |
| HC | 186 | 26.76 (15.91) | 105 (56) |
| MDD | 104 | 32.23 (16.39) | 64 (62) |
| Jena | |||
| Total | 107 | 46.76 (15.00) | 52 (49) |
| HC | 77 | 47.75 (15.93) | 36 (47) |
| MDD | 30 | 44.20 (11.92) | 16 (53) |
| LOND | |||
| Total | 130 | 49.67 (8.62) | 79 (61) |
| HC | 61 | 51.72(7.87) | 32 (53) |
| MDD | 69 | 47.86(8.85) | 47 (68) |
| MODECT | |||
| Total | 42 | 72.71 (9.25) | 28 (67) |
| HC | 0 | N/A | N/A |
| MDD | 42 | 72.71 (9.25) | 28 (67) |
| MPIP | |||
| Total | 548 | 48.66 (13.59) | 315 (57) |
| HC | 211 | 49.53 (13.02) | 124 (59) |
| MDD | 337 | 48.12 (13.90) | 191 (57) |
| Melbourne | |||
| Total | 245 | 19.42 (2.88) | 130 (53) |
| HC | 102 | 19.58 (2.97) | 54 (53) |
| MDD | 143 | 13.31 (2.80) | 76 (53) |
| Minnesota | |||
| Total | 110 | 15.47 (1.89) | 79 (72) |
| HC | 40 | 15.68 (1.98) | 26 (65) |
| MDD | 70 | 15.36 (1.83) | 53 (76) |
| Moraldilemma | |||
| Total | 70 | 18.81 (1.94) | 70 (100) |
| HC | 46 | 18.50 (1.75) | 46 (100) |
| MDD | 24 | 19.42 (2.14) | 24 (100) |
| NESDA | |||
| Total | 219 | 38.11 (10.32) | 145 (66) |
| HC | 65 | 40.29 (9.67) | 42 (65) |
| MDD | 154 | 37.19 (10.45) | 103 (67) |
| QTIM | |||
| Total | 386 | 22.08 (3.25) | 267 (69) |
| HC | 284 | 22.11 (3.30) | 190 (67) |
| MDD | 102 | 22.01 (3.11) | 77 (75) |
| UCSF | |||
| Total | 163 | 15.46 (1.31) | 91 (56) |
| HC | 88 | 15.32 (1.28) | 42 (48) |
| MDD | 75 | 15.63 (1.33) | 49 (65) |
| SHIP_S2 | |||
| Total | 579 | 55.01 (12.57) | 294 (51) |
| HC | 443 | 55.44 (12.80) | 198 (45) |
| MDD | 136 | 53.59 (11.68) | 96 (71) |
| SHIP_T0 | |||
| Total | 1229 | 50.15 (13.69) | 607 (49) |
| HC | 919 | 50.50 (14.18) | 405 (44) |
| MDD | 310 | 49.12 (12.04) | 202 (65) |
| SanRaffaele | |||
| Total | 45 | 49.07 (13.51) | 32 (71) |
| HC | 0 | N/A | N/A |
| MDD | 45 | 49.07 (13.51) | 32 (71) |
| Singapore | |||
| Total | 38 | 39.50 (6.43) | 18 (47) |
| HC | 16 | 38.69 (4.59) | 8(50) |
| MDD | 22 | 40.09 (7.43) | 10 (45) |
| Socat_dep | |||
| Total | 179 | 37.85 (13.34) | 161 (90) |
| HC | 100 | 36.42 (13.57) | 90 (90) |
| MDD | 79 | 39.66 (12.81) | 71 (90) |
| StanfFAA | |||
| Total | 32 | 32.71 (9.56) | 32 (100) |
| HC | 18 | 30.44 (9.96) | 18 (100) |
| MDD | 14 | 35.63 (8.14) | 14 (100) |
| StanfT1wAggr | |||
| Total | 115 | 37.18 (10.27) | 69 (60) |
| HC | 59 | 37.24 (10.43) | 36 (61) |
| MDD | 56 | 37.11 (10.09) | 33 (59) |
| TIGER | |||
| Total | 60 | 15.63 (1.34) | 38 (63) |
| HC | 11 | 15.18 (1.03) | 5 (45) |
| MDD | 49 | 15.73 (1.38) | 33 (67) |
| All sites | |||
| Total | 5365 | 39.84 (17.69) | 3227 (60) |
| HC | 3077 | 40.82(18.09) | 1706 (55) |
| MDD | 2288 | 38.52 (17.05) | 1521 (66) |