Figure 3.

Individual participant microbiome data after baseline, placebo, and Veillonella atypica FB0054 supplementation

(A) Using independent t tests, no significant changes (all comparisons p > 0.05) in alpha diversity were identified for participants throughout the study.

(B) Beta diversity (similarity of samples to other baseline samples) did not change throughout the study, although there were striking increases in beta diversity post-Veillonella in a subset of participants.

(C–F) Although there are differences between the microbiome of the participants, there were no significant patterns in terms of changes in the microbiome of each participant. (C) Four participants (VP01, VP02, VP08, and VP09) had Bacteroides as the most abundant genera in their community throughout the study. (D) One participant (VP03) had Prevotella as the most abundant genus throughout the study. (E) One participant (VP07) had large microbiome changes occur during the study. In this participant, the observed bacterial communities at baseline were dominated by Bacteroides and Alistipes, whereas at post-Veillonella treatment, they were dominated by Prevotella. This participant (VP07) also had the greatest improvement in time to exhaustion. (F) One participant (VP06) had Subdoligranulum as the most abundant genera throughout the study.