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. Author manuscript; available in PMC: 2024 Jan 12.
Published in final edited form as: Nat Rev Genet. 2023 Apr 21;24(8):535–549. doi: 10.1038/s41576-023-00599-5

Fig. 3∣. Types of single-cell expression quantitative trait locus.

Fig. 3∣

Single-cell-resolved expression matched with genotype information allows one to consider different types of expression quantitative trait locus (eQTL) mapping strategies. When mapping cell-type-specific eQTLs, the single-cell resolution is exclusively utilized to more precisely characterize transcriptionally similar cells. Variance eQTLs test for genetic variants associated with cell-to-cell variability of gene expression (versus average expression level). Finally, to map dynamic eQTLs, single cells are ordered along a continuous trajectory, and the test consists in identifying eQTLs, the strength of which is modulated by such a trajectory.