Table 2.
Ocular Symptoms of 3390 SICCA Participants by SjD Status
| Symptom | All (n = 3380) | Non-SjD (n = 1848) | SjD (n = 1532) | Difference (95% CI) | P Value |
|---|---|---|---|---|---|
| Redness | 0.021 | ||||
| None of the time | 1008 (29.8) | 531 (28.7) | 477 (31.1) | 2.4% (−0.8% to 5.6%) | |
| Some of the time | 1457 (43.1) | 788 (42.6) | 669 (43.7) | 1.0% (−2.4% to 4.4%) | |
| Half of the time | 298 (8.8) | 170 (9.2) | 128 (8.4) | −0.8% (−2.8% to 1.1%) | |
| Most of the time | 443 (13.1) | 237 (12.8) | 206 (13.4) | 0.6% (−1.7% to 3.0%) | |
| All of the time | 160 (4.7) | 112 (6.1) | 48 (3.1) | −2.9% (−4.4% to −1.5%) | |
| Itching | 0.020 | ||||
| None of the time | 662 (19.6) | 323 (17.5) | 339 (22.1) | 4.6% (1.9% to 7.4%) | |
| Some of the time | 1682 (49.8) | 913 (49.4) | 769 (50.2) | 0.8% (−2.7% to 4.2%) | |
| Half of the time | 443 (13.1) | 264 (14.3) | 179 (11.7) | −2.6% (−4.9% to −0.3%) | |
| Most of the time | 465 (13.8) | 268 (14.5) | 197 (12.9) | −1.6% (−4.0% to 0.7%) | |
| All of the time | 119 (3.5) | 74 (4.0) | 45 (2.9) | −1.1% (−2.4% to 0.2%) | |
| Tearing | <0.001 | ||||
| None of the time | 2389 (70.7) | 1165 (63.0) | 1224 (79.9) | 16.9% (13.8% to 19.9%) | |
| Some of the time | 806 (23.8) | 554 (30.0) | 252 (16.4) | −13.5% (−16.4% to −10.7%) | |
| Half of the time | 82 (2.4) | 61 (3.3) | 21 (1.4) | −1.9% (−3.0% to −0.9%) | |
| Most of the time | 50 (1.5) | 34 (1.8) | 16 (1.0) | −0.8% (−1.7% to 0.1%) | |
| All of the time | 41 (1.2) | 27 (1.5) | 14 (0.9) | −0.5% (−1.3% to 0.2%) | |
| Light sensitivity | <0.001 | ||||
| None of the time | 1200 (35.5) | 584 (31.6) | 616 (40.2) | 8.6% (5.3% to 11.9%) | |
| Some of the time | 979 (29.0) | 549 (29.7) | 430 (28.1) | −1.6% (−4.8% to 1.5%) | |
| Half of the time | 233 (6.9) | 135 (7.3) | 98 (6.4) | −0.9% (−2.7% to 0.9%) | |
| Most of the time | 528 (15.6) | 316 (17.1) | 212 (13.8) | −3.3% (−5.8% to −0.8%) | |
| All of the time | 430 (12.7) | 258 (14.0) | 172 (11.2) | −2.7% (−5.0% to −0.4%) | |
| Gritty | <0.001 | ||||
| None of the time | 927 (27.4) | 438 (23.7) | 489 (31.9) | 8.2% (5.1% to 11.3%) | |
| Some of the time | 1308 (38.7) | 712 (38.5) | 596 (38.9) | 0.4% (−3.0% to 3.7%) | |
| Half of the time | 371 (11.0) | 212 (11.5) | 159 (10.4) | −1.1% (−3.3% to 1.1%) | |
| Most of the time | 510 (15.1) | 323 (17.5) | 187 (12.2) | −5.3% (−7.7% to −2.8%) | |
| All of the time | 255 (7.5) | 157 (8.5) | 98 (6.4) | −2.1% (−3.9% to −0.3%) | |
| Burning | <0.001 | ||||
| None of the time | 1417 (41.9) | 697 (37.7) | 720 (47.0) | 9.3% (5.9% to 12.7%) | |
| Some of the time | 1095 (32.4) | 601 (32.5) | 494 (32.2) | −0.3% (−3.5% to 3.0%) | |
| Half of the time | 316 (9.3) | 212 (11.5) | 104 (6.8) | −4.7% (−6.7% to −2.7%) | |
| Most of the time | 387 (11.4) | 229 (12.4) | 158 (10.3) | −2.1% (−4.3% to 0.1%) | |
| All of the time | 156 (4.6) | 103 (5.6) | 53 (3.5) | −2.1% (−3.6% to −0.7%) | |
| Blurred vision | 0.058 | ||||
| None of the time | 1256 (37.2) | 663 (35.9) | 593 (38.7) | 2.8% (−0.5% to 6.2%) | |
| Some of the time | 1422 (42.1) | 766 (41.5) | 656 (42.8) | 1.4% (−2.0% to 4.8%) | |
| Half of the time | 269 (8.0) | 171 (9.3) | 98 (6.4) | −2.9% (−4.7% to −1.0%) | |
| Most of the time | 260 (7.7) | 158 (8.5) | 102 (6.7) | −1.9% (−3.7% to 0.0%) | |
| All of the time | 161 (4.8) | 82 (4.4) | 79 (5.2) | 0.7% (−0.8% to 2.2%) | |
| Fluctuating vision | 0.001 | ||||
| None of the time | 1594 (47.2) | 807 (43.7) | 787 (51.4) | 7.7% (4.3% to 11.1%) | |
| Some of the time | 1220 (36.1) | 691 (37.4) | 529 (34.5) | −2.9% (−6.2% to 0.4%) | |
| Half of the time | 212 (6.3) | 135 (7.3) | 77 (5.0) | −2.3% (−4.0% to −0.6%) | |
| Most of the time | 253 (7.5) | 153 (8.3) | 100 (6.5) | −1.8% (−3.6% to 0.1%) | |
| All of the time | 89 (2.6) | 55 (3.0) | 34 (2.2) | −0.8% (−1.9% to 0.4%) | |
| Pain | 0.003 | ||||
| None of the time | 1960 (58.0) | 1015 (54.9) | 945 (61.7) | 6.8% (3.4% to 10.1%) | |
| Some of the time | 764 (22.6) | 426 (23.1) | 338 (22.1) | −1.0% (−3.9% to 1.9%) | |
| Half of the time | 140 (4.1) | 89 (4.8) | 51 (3.3) | −1.5% (−2.9% to −0.1%) | |
| Most of the time | 306 (9.1) | 194 (10.5) | 112 (7.3) | −3.2% (−5.2% to −1.2%) | |
| All of the time | 200 (5.9) | 118 (6.4) | 82 (5.4) | −1.0% (−2.7% to 0.6%) | |
| Irritation while reading or driving | <0.001 | ||||
| None of the time | 956 (28.3) | 466 (25.2) | 490 (32.0) | 6.8% (3.6% to 9.9%) | |
| Some of the time | 1166 (34.5) | 632 (34.2) | 534 (34.9) | 0.7% (−2.6% to 3.9%) | |
| Half of the time | 318 (9.4) | 183 (9.9) | 135 (8.8) | −1.1% (−3.1% to 0.9%) | |
| Most of the time | 510 (15.1) | 295 (16.0) | 215 (14.0) | −1.9% (−4.4% to 0.5%) | |
| All of the time | 346 (10.2) | 220 (11.9) | 126 (8.2) | −3.7% (−5.8% to −1.6%) | |
| Irritation while watching TV or computer | <0.001 | ||||
| None of the time | 861 (25.5) | 418 (22.6) | 443 (28.9) | 6.3% (3.3% to 9.3%) | |
| Some of the time | 1141 (33.8) | 592 (32.0) | 549 (35.8) | 3.8% (0.5% to 7.1%) | |
| Half of the time | 352 (10.4) | 199 (10.8) | 153 (10.0) | −0.8% (−2.9% to 1.3%) | |
| Most of the time | 579 (17.1) | 350 (18.9) | 229 (14.9) | −4.0% (−6.6% to −1.4%) | |
| All of the time | 387 (11.4) | 248 (13.4) | 139 (9.1) | −4.3% (−6.5% to −2.2%) | |
| Uncomfortableness in wind | <0.001 | ||||
| None of the time | 1032 (30.5) | 500 (27.1) | 532 (34.7) | 7.7% (4.5% to 10.9%) | |
| Some of the time | 984 (29.1) | 537 (29.1) | 447 (29.2) | 0.1% (−3.0% to 3.3%) | |
| Half of the time | 206 (6.1) | 122 (6.6) | 84 (5.5) | −1.1% (−2.8% to 0.5%) | |
| Most of the time | 640 (18.9) | 376 (20.3) | 264 (17.2) | −3.1% (−5.8% to −0.4%) | |
| All of the time | 504 (14.9) | 302 (16.3) | 202 (13.2) | −3.2% (−5.6% to −0.7%) | |
| Uncomfortableness in dry or heated environment | 0.001 | ||||
| None of the time | 1070 (31.7) | 525 (28.4) | 545 (35.6) | 7.2% (3.9% to 10.4%) | |
| Some of the time | 931 (27.5) | 502 (27.2) | 429 (28.0) | 0.8% (−2.2% to 3.9%) | |
| Half of the time | 276 (8.2) | 166 (9.0) | 110 (7.2) | −1.8% (−3.7% to 0.1%) | |
| Most of the time | 628 (18.6) | 368 (19.9) | 260 (17.0) | −2.9% (−5.6% to −0.3%) | |
| All of the time | 456 (13.5) | 273 (14.8) | 183 (11.9) | −2.8% (−5.2% to −0.5%) | |
| Eye dryness | 2892 (85.6) | 1601 (86.6) | 1291 (84.3) | −2.4% (−4.8% to 0.1%) | 0.719 |
| Poor vision | 2135 (63.2) | 1160 (62.8) | 975 (63.6) | 0.9% (−2.5% to 4.2%) | 1.000 |
Values are number (%) or median (IQR) unless otherwise noted.