Table 4.

Anterior Segment Pathology and Clinical Signs of 3390 SICCA Participants by SjD Status

	All		Non-SjD		SjD
	Right	Left	Right	Left	Right	Left	OR (95% CI)	P Value
Manifestation
Lagophthalmos	40 (1.2)	36 (1.1)	25 (1.4)	22 (1.2)	15 (1.0)	14 (0.9)	0.74 (0.46 to 1.18)	0.204
Entropion	7 (0.2)	8 (0.2)	3 (0.2)	4 (0.2)	4 (0.3)	4 (0.3)	1.38 (0.50 to 3.80)	0.538
Ectropion	9 (0.3)	11 (0.3)	6 (0.3)	7 (0.4)	3 (0.2)	4 (0.3)	0.65 (0.26 to 1.62)	0.353
Trichiasis	66 (2.0)	50 (1.5)	32 (1.7)	26 (1.4)	34 (2.2)	24 (1.6)	1.23 (0.85 to 1.78)	0.274
Pterygium	55 (1.6)	62 (1.8)	31 (1.7)	29 (1.6)	24 (1.6)	33 (2.2)	1.15 (0.79 to 1.65)	0.467
Pingueculam	791 (23.4)	795 (23.5)	436 (23.6)	441 (23.9)	355 (23.2)	354 (23.1)	0.96 (0.86 to 1.08)	0.529
Meibomitis	684 (20.2)	694 (20.5)	367 (19.9)	373 (20.2)	317 (20.7)	321 (21.0)	1.05 (0.93 to 1.18)	0.423
Blepharitis	378 (11.2)	373 (11.0)	194 (10.5)	189 (10.2)	184 (12.0)	184 (12.0)	1.17 (1.00 to 1.36)	0.044
Corneal abnormality
Filaments	135 (4.0)	140 (4.1)	33 (1.8)	38 (2.1)	102 (6.7)	102 (6.7)	3.63 (2.76 to 4.78)	<0.001
Corneal vascularization	37 (1.1)	43 (1.3)	8 (0.4)	15 (0.8)	29 (1.9)	28 (1.8)	3.02 (1.86 to 4.91)	<0.001
Corneal scarring	100 (3.0)	104 (3.1)	40 (2.2)	46 (2.5)	60 (3.9)	58 (3.8)	1.70 (1.28 to 2.25)	<0.001
Corneal ulceration	3 (0.1)	8 (0.2)	1 (0.1)	1 (0.1)	2 (0.1)	7 (0.5)	5.43 (1.17 to 25.13)	0.031
Tear film
Abnormal TBUT	2733 (80.9)	2726 (80.7)	1363 (73.8)	1372 (74.2)	1370 (89.4)	1354 (88.4)	2.83 (2.47 to 3.23)	<0.001
Debris	1329 (39.3)	1337 (39.6)	483 (26.1)	496 (26.8)	846 (55.2)	841 (54.9)	3.40 (3.07 to 3.76)	<0.001
Abnormal Schirmer I	1126 (33.3)	1104 (32.7)	405 (21.9)	384 (20.8)	721 (47.1)	720 (47.0)	3.28 (2.95 to 3.65)	<0.001

TBUT, tear break-up time.

Values are number (%) or mean ± SD.