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TPL regulates the JAK2/STAT3 pathway via NONHSAT227927.1. Effects of NONHSAT227927 on the expression of JAK2, STAT3, p-JAK2 and p-STAT3 were evaluated by western blot analysis. Data are expressed as mean ± standard deviation of 3 independent repeats. *P<0.05, ***P<0.001. TPL, Triptolide; p-, Phosphorylation-; AS-PBMC, Ankylosing spondylitis-Peripheral blood mononuclear cell; FLS, fibroblast-like synoviocyte; PF, AS-PBMC+AS-FLS; si-NC, small interfering negative control.
